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The molecular mechanism underlying the association of\n                    <jats:italic>KCNQ1<\/jats:italic>\n                    with the onset of type 2 diabetes has remained unclear; however, we have now found that a paternal allelic mutation of\n                    <jats:italic>Kcnq1<\/jats:italic>\n                    results in the up-regulation of the neighboring imprinted gene cyclin-dependent kinase inhibitor 1C (\n                    <jats:italic>Cdkn1c<\/jats:italic>\n                    ), a cell cycle inhibitor, in pancreatic \u03b2-cells of mice, with this effect being mediated by epigenetic modification of the\n                    <jats:italic>Cdkn1c<\/jats:italic>\n                    promoter. These changes seem to be responsible for the reduced pancreatic \u03b2-cell mass and impaired glucose tolerance characteristics of\n                    <jats:italic>Kcnq1<\/jats:italic>\n                    mutant mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1422104112","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T22:01:34Z","timestamp":1435010494000},"page":"8332-8337","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Paternal allelic mutation at the\n                    <i>Kcnq1<\/i>\n                    locus reduces pancreatic \u03b2-cell mass by epigenetic modification of\n                    <i>Cdkn1c<\/i>"],"prefix":"10.1073","volume":"112","author":[{"given":"Shun-ichiro","family":"Asahara","sequence":"first","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 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