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A positional cloning strategy was used to identify 22 genes from the\n                    <jats:italic>Flv<\/jats:italic>\n                    gene interval including 10 members of the 2\u2032-5\u2032-oligoadenylate synthetase gene family. One 2\u2032-5\u2032-oligoadenylate synthetase gene,\n                    <jats:italic>Oas1b<\/jats:italic>\n                    , was identified as\n                    <jats:italic>Flv<\/jats:italic>\n                    by correlation between genotype and phenotype in nine mouse strains. Susceptible mouse strains produce a protein lacking 30% of the C-terminal sequence as compared with the resistant counterpart because of the presence of a premature stop codon. The\n                    <jats:italic>Oas1b<\/jats:italic>\n                    gene differs from all the other murine\n                    <jats:italic>Oas<\/jats:italic>\n                    genes by a unique four-amino acid deletion in the P-loop located within the conserved RNA binding domain. Expression of the resistant allele of\n                    <jats:italic>Oas1b<\/jats:italic>\n                    in susceptible embryo fibroblasts resulted in partial inhibition of the replication of a flavivirus but not of an alpha togavirus.\n                  <\/jats:p>","DOI":"10.1073\/pnas.142287799","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T18:26:28Z","timestamp":1027880788000},"page":"9322-9327","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":238,"title":["Positional cloning of the murine flavivirus resistance gene"],"prefix":"10.1073","volume":"99","author":[{"given":"Andrey A.","family":"Perelygin","sequence":"first","affiliation":[{"name":"Department of Biology, Georgia State University, Atlanta, GA 30303; and School of Biology, Georgia Institute of Technology, Atlanta, GA 30332"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Scherbik","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgia State University, Atlanta, GA 30303; 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