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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Although we know much about the molecular mechanisms of cross-presentation, its actual contribution to cytotoxic T cell (CTL) immunity under physiological conditions in vivo is still unclear. Cross-presentation is based on the idea that dendritic cells (DCs) are the only professional antigen-presenting cells able to prime na\u00efve T cells. If DCs are not directly infected, they must take up antigen and present it indirectly. However, recent evidence suggests that other cells also may be involved in T cell priming, which probably makes cross-presentation less central. This study shows that cross-priming DCs generate highly restricted CTL repertoires, biased to strong MHC I binding epitopes only. 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