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We also replaced the\n                    <jats:italic>TREX1<\/jats:italic>\n                    WT gene in mice with the\n                    <jats:italic>TREX1<\/jats:italic>\n                    D18N mutated gene and showed how this mutation causes a lupus-like disease. Together, the TREX1 D18N\u2013dsDNA structure and the spontaneous disease exhibited in the\n                    <jats:italic>TREX1<\/jats:italic>\n                    D18N mouse help to define how TREX1 degrades dsDNA to prevent this molecule from acting as an autoantigen in the mouse and, most likely, in humans to promote autoimmune disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1423804112","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T22:23:05Z","timestamp":1428358985000},"page":"5117-5122","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":187,"title":["Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease"],"prefix":"10.1073","volume":"112","author":[{"given":"Jessica L.","family":"Grieves","sequence":"first","affiliation":[{"name":"Department of Biochemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Fye","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Grayson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hollis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred W.","family":"Perrino","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1016\/S0021-9258(18)94303-6","article-title":"Properties of deoxyribonuclease 3 from mammalian tissues","volume":"244","author":"Lindahl T","year":"1969","unstructured":"T Lindahl, JA Gally, GM Edelman, Properties of deoxyribonuclease 3 from mammalian tissues. 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