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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,2,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mammalian sperm fertility depends on coordinated activation of two sperm-specific ion channels, the alkalization-activated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -permeable sperm channel and a sperm pH-regulated K\n                    <jats:sup>+<\/jats:sup>\n                    current (KSPER) channel; both are required for fertility. In the mouse, the KSPER channel is thought to involve a complex of a pore-forming ion channel protein and subunit encoded by the\n                    <jats:italic>slo3<\/jats:italic>\n                    gene subunit and the leucine-rich-repeat-containing protein 52 (LRRC52) auxiliary subunit. We now show that KO of LRRC52 results in severely compromised fertility and shifts KSPER current activation away from the physiological range. Furthermore, utilizing genotypes with differing average amounts of KSPER current, we show that sperm fertility exhibits a steep dependence on the amount of available KSPER current. The results establish that LRRC52 is a critical determinant of sperm KSPER function and essential to support normal fertility.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1423869112","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T23:13:27Z","timestamp":1423523607000},"page":"2599-2604","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":65,"title":["SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility"],"prefix":"10.1073","volume":"112","author":[{"given":"Xu-Hui","family":"Zeng","sequence":"first","affiliation":[{"name":"Institute of Life Science, Nanchang University, Nanchang, Jiangxi, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengtao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Life Science, Nanchang University, Nanchang, Jiangxi, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Lingle","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0180275"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/j.1939-4640.1996.tb01797.x","article-title":"Hyperactivated motility in sperm","volume":"17","author":"Suarez SS","year":"1996","unstructured":"SS Suarez, Hyperactivated motility in sperm. 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