{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:44:55Z","timestamp":1792525495364,"version":"4.5.0"},"reference-count":50,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n                    Gene-for-gene disease resistance typically includes a programmed cell death response known as the hypersensitive response (HR). The\n                    <jats:italic>Arabidopsis thaliana dnd1<\/jats:italic>\n                    mutant was previously isolated as a line that failed to produce the HR in response to avirulent\n                    <jats:italic>Pseudomonas syringae<\/jats:italic>\n                    pathogens; plants homozygous for the recessive\n                    <jats:italic>dnd1<\/jats:italic>\n                    -\n                    <jats:italic>1<\/jats:italic>\n                    mutation still carry out effective gene-for-gene resistance. The\n                    <jats:italic>dnd1<\/jats:italic>\n                    -\n                    <jats:italic>1<\/jats:italic>\n                    mutation also causes constitutive systemic resistance and elevated levels of salicylic acid. In the present study, a positional cloning approach was used to isolate\n                    <jats:italic>DND1. DND1<\/jats:italic>\n                    encodes the same protein as AtCNGC2, a cyclic nucleotide-gated ion channel of previously unknown organismal function that can allow passage of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , K\n                    <jats:sup>+<\/jats:sup>\n                    and other cations [Leng, Q., Mercier, R. W., Yao, W. &amp; Berkowitz, G. A. (1999)\n                    <jats:italic>Plant Physiol.<\/jats:italic>\n                    121, 753\u2013761]. By using a nahG transgene, we found that salicylic acid is required for the elevated resistance caused by the\n                    <jats:italic>dnd1<\/jats:italic>\n                    mutation but that removal of salicylic acid did not completely eliminate the dwarf and loss-of-HR phenotypes of mutant\n                    <jats:italic>dnd1<\/jats:italic>\n                    plants. A stop codon that would severely truncate the\n                    <jats:italic>DND1<\/jats:italic>\n                    gene product was identified in the\n                    <jats:italic>dnd1<\/jats:italic>\n                    -\n                    <jats:italic>1<\/jats:italic>\n                    allele. This demonstrates that broad-spectrum disease resistance and inhibition of the HR can be activated in plants by disruption of a cyclic nucleotide-gated ion channel.\n                  <\/jats:p>","DOI":"10.1073\/pnas.150005697","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:41:48Z","timestamp":1027680108000},"page":"9323-9328","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":502,"title":["The\n                    <i>Arabidopsis dnd1<\/i>\n                    \u201cdefense, no death\u201d gene encodes a mutated cyclic nucleotide-gated ion channel"],"prefix":"10.1073","volume":"97","author":[{"given":"Steven J.","family":"Clough","sequence":"first","affiliation":[{"name":"Department of Crop Sciences and Physiological and Molecular Plant Biology Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and Department of Plant Pathology, University of Wisconsin at Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Fengler","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Physiological and Molecular Plant Biology Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and Department of Plant Pathology, University of Wisconsin at Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-ching","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Physiological and Molecular Plant Biology Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and Department of Plant Pathology, University of Wisconsin at Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Lippok","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Physiological and Molecular Plant Biology Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and Department of Plant Pathology, University of Wisconsin at Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Roger K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Physiological and Molecular Plant Biology Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and Department of Plant Pathology, University of Wisconsin at Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Bent","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Physiological and Molecular Plant Biology Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and Department of Plant Pathology, University of Wisconsin at Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,7,18]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.arplant.48.1.575","volume":"48","author":"Hammond-Kosack K E","year":"1997","unstructured":"K E Hammond-Kosack, J D G Jones Annu Rev Plant Mol Biol 48, 575\u2013607 (1997).","journal-title":"Annu Rev Plant Mol Biol"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1369-5266(99)80049-1","volume":"2","author":"Martin G B","year":"1999","unstructured":"G B Martin Curr Opin Plant Biol 2, 273\u2013279 (1999).","journal-title":"Curr Opin Plant Biol"},{"key":"e_1_3_4_3_2","volume-title":"The Hypersensitive Reaction in Plants to Pathogens: A Resistance Phenomenon","author":"Goodman R N","year":"1994","unstructured":"R N Goodman, A J Novacky The Hypersensitive Reaction in Plants to Pathogens: A Resistance Phenomenon (Am. 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