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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,2,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    To our knowledge, this work describes the first genome-wide annotation of transcriptional start sites in\n                    <jats:italic>Vibrio cholerae<\/jats:italic>\n                    and the discovery and characterization of a regulatory RNA, named VqmR, which controls collective behaviors in this major human pathogen. We show that VqmR is activated by the VqmA transcriptional regulator. VqmR represses expression of multiple mRNA targets including those encoding the Rtx (repeats in toxin) toxin and VpsT, which is required for biofilm formation. Indeed, we show that VqmR controls biofilm formation through repression of\n                    <jats:italic>vpsT<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.1500203112","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T23:18:45Z","timestamp":1422919125000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":235,"title":["Differential RNA-seq of\n                    <i>Vibrio cholerae<\/i>\n                    identifies the VqmR small RNA as a regulator of biofilm formation"],"prefix":"10.1073","volume":"112","author":[{"given":"Kai","family":"Papenfort","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad U.","family":"F\u00f6rstner","sequence":"additional","affiliation":[{"name":"Research Center for Infectious Diseases (ZINF), University of W\u00fcrzburg, D-97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ping","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Research Center for Infectious Diseases (ZINF), University of W\u00fcrzburg, D-97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie L.","family":"Bassler","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and"},{"name":"Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012427","article-title":"Bacterial quorum sensing: Its role in virulence and possibilities for its control","volume":"2","author":"Rutherford ST","year":"2012","unstructured":"ST Rutherford, BL Bassler, Bacterial quorum sensing: Its role in virulence and possibilities for its control. 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