{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:10:41Z","timestamp":1790521841632,"version":"4.1.0"},"reference-count":32,"publisher":"National Academy of Sciences","issue":"7","license":[{"start":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T00:00:00Z","timestamp":1438473600000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK89507"],"award-info":[{"award-number":["DK89507"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM59026"],"award-info":[{"award-number":["GM59026"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI102921"],"award-info":[{"award-number":["AI102921"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["Career Award for Medical Scientists"],"award-info":[{"award-number":["Career Award for Medical Scientists"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["LeRoy Matthews Award DANDEK12L0"],"award-info":[{"award-number":["LeRoy Matthews Award DANDEK12L0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,2,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Cooperation is subject to social cheating. Cheats benefit from the activity of cooperators and gain a fitness advantage. One way higher organisms prevent infiltration by cheats is policing: Cooperators penalize cheats at some cost to themselves. Cooperating groups of bacteria are susceptible to social cheating, but little is known about bacterial policing. We have built on an understanding a quorum-sensing regulated cooperative activity in\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    to show that quorum sensing control of and resistance to cyanide production serves as a cheater policing mechanism. Understanding how bacteria cooperate and how they control social cheats has evolutionary implications, provides important insights about ways to control bacterial populations, and has ramifications with respect to synthetic system design.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1500704112","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T23:18:45Z","timestamp":1422919125000},"page":"2187-2191","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":226,"title":["Quorum sensing and policing of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    social cheaters"],"prefix":"10.1073","volume":"112","author":[{"given":"Meizhen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, ZJ 310012, China;"},{"name":"Department of Microbiology, University of Washington, Seattle, WA 98195-7735; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Washington, Seattle, WA 98195-7735; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajai A.","family":"Dandekar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Washington, Seattle, WA 98195-7735; and"},{"name":"Department of Medicine, University of Washington, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Peter","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Washington, Seattle, WA 98195-7735; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.7.2066-2079.2003"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.7.2080-2095.2003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.1.197"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12830"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493556"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1490"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.10.3127-3132.1997"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.24.7155-7163.1995"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06279"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155635"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1461"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227289"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705653104"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.01.051"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.98"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089402"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02744"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2000.0727"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065507"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013210108"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510260103"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/373209a0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2132993100"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04326"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014695108"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2003.12.009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.21.6207-6214.2001"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07436.x"},{"key":"e_1_3_3_29_2","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook J","year":"1989","unstructured":"J Sambrook, EF Fritsch, T Maniatis Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab Press, Plainview, NY, 1989)."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/35023079"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503005102"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.13"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1500704112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1500704112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:41:40Z","timestamp":1649806900000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1500704112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,2,17]]}},"alternative-id":["10.1073\/pnas.1500704112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1500704112","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725347760.793512445","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]},"assertion":[{"value":"2015-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}