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Here we report that the relative hydrophobicity of T-cell receptor contact residues is markedly enriched in immunogenic major histocompatibility complex class I epitopes in both human and murine MHCs, and in both self and pathogen-derived immunogenic epitopes. Incorporating hydrophobicity into T-cell epitope prediction models increases the efficiency of epitope identification, which will manifest in the time and cost of T-cell vaccine development. Amino acid hydrophobicity may represent a biochemical basis by which T cells discriminate immunogenic epitopes within the background of self peptides.<\/jats:p>","DOI":"10.1073\/pnas.1500973112","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T23:17:43Z","timestamp":1427152663000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":240,"title":["TCR contact residue hydrophobicity is a hallmark of immunogenic CD8\n                    <sup>+<\/sup>\n                    T cell epitopes"],"prefix":"10.1073","volume":"112","author":[{"given":"Diego","family":"Chowell","sequence":"first","affiliation":[{"name":"Simon A. Levin Mathematical, Computational, and Modeling Sciences Center,"},{"name":"Center for Personalized Diagnostics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri","family":"Krishna","sequence":"additional","affiliation":[{"name":"Center for Personalized Diagnostics, and"},{"name":"School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-1230","authenticated-orcid":false,"given":"Pablo D.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Cocita","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington, Seattle, WA 98195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington, Seattle, WA 98195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington, Seattle, WA 98195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Klavinskis","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph N.","family":"Blattman","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Personalized Diagnostics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.221"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095910"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00185-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2224"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068883"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/351290a0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050595"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.4049\/jimmunol.152.8.3913","article-title":"Definition of specific peptide motifs for four major HLA-A alleles","volume":"152","author":"Kubo RT","year":"1994","unstructured":"RT Kubo, , Definition of specific peptide motifs for four major HLA-A alleles. 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