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Melanocytes derived from NF1 hESCs reproduced the hyperpigmentation phenotype in vitro and were characterized by deregulation of melanogenesis factors. The model allowed us to identify the cellular pathways involved in this phenotype. The hyperpigmentation phenotype could be rescued by small molecules, demonstrating the potential of pluripotent stem cells as models for pigmentation disorders.<\/jats:p>","DOI":"10.1073\/pnas.1501032112","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T23:00:04Z","timestamp":1436223604000},"page":"9034-9039","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells"],"prefix":"10.1073","volume":"112","author":[{"given":"Jennifer","family":"Allouche","sequence":"first","affiliation":[{"name":"INSERM U-861, Institut des cellules Souches pour le Traitement et l'Etude des Maladies monog\u00e9niques (I-Stem), Association Fran\u00e7aise contre les Myopathies (AFM), 91030 Evry Cedex, France;"},{"name":"Universit\u00e9 d'Evry Val d'Essonne (UEVE) U-861, I-Stem, 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