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Evolutionary changes in such sexually dimorphic features are often a result of changes in the\n                    <jats:italic>cis<\/jats:italic>\n                    -regulatory sequences of the DSX target genes. When a particular target gene is directly regulated by DSX in multiple tissues, evolutionarily conflicting constraints may be generated. The research we present here reveals that such conflict can be solved by deploying different\n                    <jats:italic>cis<\/jats:italic>\n                    -regulatory modules (sharing the DSX-binding site) for different tissues. This mechanism could also apply to other transcription factors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1501192112","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T23:13:27Z","timestamp":1423523607000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["Constraints on the evolution of a\n                    <i>doublesex<\/i>\n                    target gene arising from doublesex\u2019s pleiotropic deployment"],"prefix":"10.1073","volume":"112","author":[{"given":"Shengzhan D.","family":"Luo","sequence":"first","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Baker","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.03.001"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(02)02769-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)00403-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000365"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.04.005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.06.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(07)59002-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.09.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387003-2.00004-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.04.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.08.025"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700488104"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00130-1"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.030"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1554\/0014-3820(2000)054[1079:PEDBAT]2.0.CO;2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.023"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2687"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07798.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.1.42"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.052"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000168"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-659"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.11.035"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.065227"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)48631-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.111.088047"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.03.004"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.3.6.831"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0022-3565(25)24559-1","article-title":"Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbit","volume":"272","author":"Shehin-Johnson SE","year":"1995","unstructured":"SE Shehin-Johnson, DE Williams, S Larsen-Su, DM Stresser, RN Hines, Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbit. 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