{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:30:48Z","timestamp":1781109048980,"version":"3.54.1"},"reference-count":59,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,6,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Cell transplantation can restore function in neurodegenerative disorders, but the low rate of functional integration of donor cells into host is a major limiting factor for clinical application. This problem is closely related to the long-standing view that donor cells must be transplanted intraneurally. We show that glial scar, which is common in neurodegenerative conditions, inhibits the survival of intraneurally transplanted cells in our rat glial scar model in the auditory system. However, cells placed on the surface of scar tissue autonomously enter the nerve and become functionally integrated into the host. The glial scar, normally considered to be a barrier to cell transplantation, includes important structural and chemical cues that are disrupted by intraneural delivery but preserved by surface transplantation.<\/jats:p>","DOI":"10.1073\/pnas.1501835112","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T23:01:21Z","timestamp":1434409281000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration"],"prefix":"10.1073","volume":"112","author":[{"given":"Tetsuji","family":"Sekiya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Holley","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Hashido","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie T.","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomi","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-7013","authenticated-orcid":false,"given":"Tatsunori","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"9","article-title":"Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites","volume":"522","author":"Bj\u00f6rklund A","year":"1983","unstructured":"A Bj\u00f6rklund, U Stenevi, RH Schmidt, SB Dunnett, FH Gage, Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol Scand Suppl 522, 9\u201318 (1983).","journal-title":"Acta Physiol Scand Suppl"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408484111"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.12.024"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1326"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709002105"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.04.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.2.JNS091817"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23093"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/63.1.5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.11.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05478.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04213.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/416636a"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1937.02260180118008"},{"key":"e_1_3_3_15_2","first-page":"109","article-title":"The development of the central-peripheral transitional zone of the rat cochlear nerve. A light microscopic study","volume":"155","author":"Fraher JP","year":"1987","unstructured":"JP Fraher, FJ Delanty, The development of the central-peripheral transitional zone of the rat cochlear nerve. A light microscopic study. J Anat 155, 109\u2013118 (1987).","journal-title":"J Anat"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02427.2000"},{"key":"e_1_3_3_17_2","first-page":"23","volume-title":"Generation of Electrical Activity in the Nervous System and Muscles. Neurophysiological Monitoring","author":"Moller AR","year":"2011","unstructured":"AR Moller Generation of Electrical Activity in the Nervous System and Muscles. Neurophysiological Monitoring (Springer, New York), pp. 23\u201341 (2011)."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(88)90021-4"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01939380"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131058"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2121-13.2013"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5251.978"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2074"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/338161a0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11415"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.08.017"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0419-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142849"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178310"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3070"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.01.036"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.07.030"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-18-07034.2003"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1344.032"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2120-04.2004"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8346-x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4369-13.2014"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2927-14.2014"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02302-5"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3257-09.2009"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6877"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.08.018"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0758-12.2012"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20820"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19420161.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1195"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.243063"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05161"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161335.62139.80"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90150-1"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00252"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7503.1314"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.08.033"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00910.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104309200"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00174013"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.12.017"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.04.016"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083365"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1501835112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:17:13Z","timestamp":1649809033000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1501835112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":59,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2015,6,30]]}},"alternative-id":["10.1073\/pnas.1501835112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1501835112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]},"assertion":[{"value":"2015-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}