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Here, we report that C5orf30 encodes a 206-aa protein that is highly expressed in RA synovial fibroblasts (RASFs), a cell type implicated in causing joint damage. Importantly inhibition of C5orf30 increases the autoaggressive phenotype of RASFs in vitro and increases joint inflammation and damage in murine inflammatory arthritis. Our data reveals C5orf30 to be a negative regulator of tissue breakdown modulating the autoaggressive phenotype that is characteristic of RASFs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1501947112","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T22:59:39Z","timestamp":1440716379000},"page":"11618-11623","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis"],"prefix":"10.1073","volume":"112","author":[{"given":"Munitta","family":"Muthana","sequence":"first","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hawtree","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wilshaw","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimear","family":"Linehan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Dublin Academic Medical Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin D04 W6F6, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Roberts","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Khetan","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gbadebo","family":"Adeleke","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Wright","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Akil","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Fearon","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Dublin Academic Medical Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin D04 W6F6, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Veale","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Dublin Academic Medical Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin D04 W6F6, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ciani","sequence":"additional","affiliation":[{"name":"Centre for Membrane Interactions and Dynamics, and Krebs Institute, Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Academic Unit of Rheumatology, University of Sheffield, Sheffield S10 2RX, United Kingdom;"},{"name":"Department of Rheumatology, Dublin Academic Medical Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin D04 W6F6, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/ard.2005.041079","article-title":"Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles","volume":"65","author":"Linn-Rasker SP","year":"2006","unstructured":"SP Linn-Rasker, , Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. 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