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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>By studying premalignant conditions, we can gain a better understanding of the sources of genomic instability and improve cancer prevention and treatment. Because retrotransposition has been observed in many gastrointestinal epithelial cancer types, we focused on L1 mobilization as a source of instability in cancer. Here, we demonstrate that L1 retrotransposition is active in esophageal adenocarcinoma and its precursor, Barrett\u2019s esophagus (BE). We detected clonal populations with precursor cells marked by L1 retrotransposition events either in the normal esophagus or BE. These clones expanded in the BE or esophageal adenocarcinoma (EAC), indicating that somatic L1 insertions are not only potential mutagens in the development of EAC, but also useful markers of tumor clones as well.<\/jats:p>","DOI":"10.1073\/pnas.1502474112","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T22:41:06Z","timestamp":1439851266000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":125,"title":["LINE-1 expression and retrotransposition in Barrett\u2019s esophagus and esophageal carcinoma"],"prefix":"10.1073","volume":"112","author":[{"given":"Tara T.","family":"Doucet-O'Hare","sequence":"first","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"},{"name":"Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemanja","family":"Rodi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Darbari","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Abril","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungbin A.","family":"Choi","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Young Ahn","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine and Department of Oncology, Johns Hopkins University, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Anders","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen H.","family":"Burns","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"},{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine and Department of Oncology, Johns Hopkins University, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Haig H.","family":"Kazazian","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,8,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4292\/wjgpt.v5.i3.105","article-title":"Diagnosis and treatment of gastroesophageal reflux disease","volume":"5","author":"Badillo R","year":"2014","unstructured":"R Badillo, D Francis, Diagnosis and treatment of gastroesophageal reflux disease. 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