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U.S.A."],"published-print":{"date-parts":[[2015,4,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Elevated levels of cholesterol and other lipid abnormalities are common diseases of adults. Cholesterol is an essential nutrient for\n                    <jats:italic>Borrelia<\/jats:italic>\n                    . To test whether increased levels of cholesterol could affect the infection with\n                    <jats:italic>Borrelia<\/jats:italic>\n                    , we used two types of mice with different deficiencies in cholesterol transport that result in increased cholesterol levels and infected them with two species of\n                    <jats:italic>Borrelia<\/jats:italic>\n                    . Infection with the agent of Lyme disease resulted in higher severity, increased number of bacteria in the joints, and ankle swelling. The higher mortality found in infections with relapsing-fever\n                    <jats:italic>Borrelia<\/jats:italic>\n                    was associated with an apolipoprotein E deficiency and was independent of cholesterol levels. Elevated serum lipids are common diseases that could be a risk factor for increased severity in Lyme disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1502561112","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T22:41:48Z","timestamp":1428964908000},"page":"5491-5496","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever\n                    <i>Borrelia<\/i>"],"prefix":"10.1073","volume":"112","author":[{"given":"Alvaro","family":"Toledo","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier D.","family":"Monz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology 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