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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,6,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Cholesterol-derived steroid hormones are critical mediators in development, reproduction, behavior, and stress response. Steroid biosynthesis occurs in hormone-dependent steroidogenic cells, which are defined by their ability to cleave cholesterol to pregnenolone in mitochondria, the adrenal cortex, and gonads. The rate-limiting step in steroid biosynthesis is the transport of cholesterol from intracellular stores into mitochondria. Translocator protein (TSPO) is a high-affinity drug- and cholesterol-binding protein important for cholesterol import into mitochondria. Two distinct genetically engineered\n                    <jats:italic>Tspo<\/jats:italic>\n                    mouse mutants were generated to induce gonadal and steroidogenic cell-specific\n                    <jats:italic>Tspo<\/jats:italic>\n                    deletion. Our studies show the importance of TSPO for murine development as well as for hormone-induced steroidogenesis, suggesting a key role for TSPO in the development and function of the mammalian acute stress response.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1502670112","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T10:35:29Z","timestamp":1432722929000},"page":"7261-7266","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":137,"title":["Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation"],"prefix":"10.1073","volume":"112","author":[{"given":"Jinjiang","family":"Fan","sequence":"first","affiliation":[{"name":"The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Campioli","sequence":"additional","affiliation":[{"name":"The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Midzak","sequence":"additional","affiliation":[{"name":"The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Culty","sequence":"additional","affiliation":[{"name":"The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada;"},{"name":"Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada;"},{"name":"Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.06.005"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3295"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248725"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1534"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(03)00101-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260590"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216771"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.12.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1159"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.12.8940403"},{"key":"e_1_3_3_11_2","first-page":"369","article-title":"Structural and functional evolution of the translocator protein (18 kDa)","volume":"12","author":"Fan J","year":"2012","unstructured":"J Fan, P Lindemann, MGJ Feuilloley, V Papadopoulos, Structural and functional evolution of the translocator protein (18 kDa). 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