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The cause of these dyskinesias has been attributed to receptor supersensitivity and uncontrolled neuronal excitability. Here we demonstrate in multiple preclinical models of\n                    <jats:sc>l<\/jats:sc>\n                    -DOPA\u2013induced dyskinesias and PD that expression levels of \u03b2-arrestin2 can alter manifestation of these dyskinesias by reducing receptor supersensitivity while maintaining the therapeutic effect of\n                    <jats:sc>l<\/jats:sc>\n                    -DOPA. Thus novel drugs that increase \u03b2-arrestin\u2013dependent function at dopamine receptors may be useful in ameliorating PD motor symptoms without inducing dyskinesias.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1502740112","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T17:24:52Z","timestamp":1430414692000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":108,"title":["Targeting \u03b2-arrestin2 in the treatment of\n                    <scp>l<\/scp>\n                    -DOPA\u2013induced dyskinesia in Parkinson\u2019s disease"],"prefix":"10.1073","volume":"112","author":[{"given":"Nikhil M.","family":"Urs","sequence":"first","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bido","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR 5293, Universit\u00e9 de Bordeaux, 33000 Bordeaux, France;"},{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR 5293, CNRS, 33000 Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya L.","family":"Daigle","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Bass","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University at Buffalo, The State Uiversity of New York, Buffalo, NY 14260; 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