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U.S.A."],"published-print":{"date-parts":[[2015,6,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Based on several studies, including ours, we estimate that 40\u201370 million individuals carry a chromosomally integrated copy of the human herpesvirus 6 (HHV-6) genome in every cell of their body. This condition is referred to as inherited chromosomally integrated HHV-6 (iciHHV-6). The regions targeted for integration are telomeres, which play important roles in the self-renewal capacity of cells. Whether iciHHV-6 is associated with disease remains unknown. After conducting a population screen (\n                    <jats:italic>n<\/jats:italic>\n                    = 20,000), our results indicate that the prevalence of angina is three times greater in iciHHV-6+ subjects relative to iciHHV-6\u2212 ones. Furthermore, iciHHV-6+ subjects have shorter telomeres, a result that may explain, at least in part, how iciHHV-6 may contribute to the development of angina.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1502741112","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T23:01:21Z","timestamp":1434409281000},"page":"8058-8063","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":99,"title":["Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris"],"prefix":"10.1073","volume":"112","author":[{"given":"Annie","family":"Gravel","sequence":"first","affiliation":[{"name":"Division of Infectious Disease and Immunity, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Dubuc","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Immunity, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Morissette","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Immunity, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth H.","family":"Sedlak","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, WA 98102;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Jerome","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle, WA 98102;"},{"name":"Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98102;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Flamand","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Immunity, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G2;"},{"name":"Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 0A6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2876520"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.6.1271"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91893-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/428060"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890400110"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1382"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01169-10"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)79251-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084322"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.217240"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","unstructured":"B Geraudie Quantitation of human herpesvirus-6A -6B and -7 DNAs in whole blood mononuclear and polymorphonuclear cell fractions from healthy blood donors. 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