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Many antibodies against H5 are lightly mutated and may arise from naive B cells, explaining the low antigenicity of H5N1 vaccines relative to seasonal influenza vaccines and supporting the idea that multiple exposures are necessary to develop a strong immune response to H5N1 strains.<\/jats:p>","DOI":"10.1073\/pnas.1502762112","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T22:45:12Z","timestamp":1436827512000},"page":"9346-9351","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites"],"prefix":"10.1073","volume":"112","author":[{"given":"Katie L.","family":"Winarski","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University School of Medicine, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Yu","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University School of Medicine, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Sapparapu","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University School of Medicine, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James. 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