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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Genetic, biochemical, and animal model studies have implicated with-no-lysine kinase 4 (WNK4) in regulation of the balance between renal salt reabsorption and K secretion. It has been proposed that serum\/glucocorticoid-induced kinase 1 (SGK1)-induced phosphorylation of WNK4 plays an important role in switching from inhibiting KCNJ1 (ROMK) channels during volume depletion to promoting K secretion during increasing K intake. However, it is not understood why a high SGK1 level fails to stimulate ROMK channels during the volume depletion, whereas it increases ROMK channel activity and K secretion during high K intake. The present study provides insights into the mechanism illustrating how SFK-induced phosphorylation of WNK4 regulates ROMK to distinguish the physiologic response to hyperkalemia and volume depletion.<\/jats:p>","DOI":"10.1073\/pnas.1503437112","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T01:41:08Z","timestamp":1427247668000},"page":"4495-4500","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)"],"prefix":"10.1073","volume":"112","author":[{"given":"Dao-Hong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacology, New York Medical College, Valhalla, NY 10595;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, New York Medical College, Valhalla, NY 10595;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Orlando","family":"Yarborough","sequence":"additional","affiliation":[{"name":"Department of bGenetics and"},{"name":"Howard Hughes Medical Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute I.","family":"Scholl","sequence":"additional","affiliation":[{"name":"Department of bGenetics and"},{"name":"Howard Hughes Medical Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Giebisch","sequence":"additional","affiliation":[{"name":"Department of dCellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520; 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