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Welch Foundation","doi-asserted-by":"crossref","award":["E-0004"],"award-info":[{"award-number":["E-0004"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Estrogen receptor \u03b2 (ER\u03b2) is thought to be the predominant nuclear receptor that regulates estrogen signaling in a wide variety of tissues. In several circumstances, it can oppose the effects of ER\u03b1. Here, we generated a novel ER\u03b2 exon 3-deleted mouse model (ER\u03b2-\u0394ex3) in which the first zinc finger of the DNA binding domain is missing but the remaining C-terminus part of the receptor is present. We observed that mutant male mice were normal but females were anovulatory. Thus, this work demonstrates that most of the physiological functions of ER\u03b2 do not involve estrogen response element binding.<\/jats:p>","DOI":"10.1073\/pnas.1504944112","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T22:23:05Z","timestamp":1428358985000},"page":"5135-5140","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Estrogen receptor \u03b2 exon 3-deleted mouse: The importance of non-ERE pathways in ER\u03b2 signaling"],"prefix":"10.1073","volume":"112","author":[{"given":"Laure","family":"Maneix","sequence":"first","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Antonson","sequence":"additional","affiliation":[{"name":"Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Humire","sequence":"additional","affiliation":[{"name":"Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Rochel-Maia","sequence":"additional","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Omoto","sequence":"additional","affiliation":[{"name":"Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Warner","sequence":"additional","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-\u00c5ke","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; and"},{"name":"Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15677"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242735799"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041617498"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0731830100"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.23.8542-8552.2003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602194103"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511271103"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403041101"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117772108"},{"key":"e_1_3_3_10_2","first-page":"5331","article-title":"Frequent loss of estrogen receptor-beta expression in prostate cancer","volume":"61","author":"Horvath LG","year":"2001","unstructured":"LG Horvath, , Frequent loss of estrogen receptor-beta expression in prostate cancer. 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