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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,8,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Primary aldosteronism (PA) represents the most common adrenal disease and cause of secondary hypertension. However, little is known regarding adrenal cellular origins. Recently, subcapsular aldosterone-producing cell clusters (APCCs) were observed in normal adrenals. We hypothesize that APCCs are a contributor to PA. Here, we characterized the APCC transcriptome and show that\n                    <jats:italic>CYP11B2<\/jats:italic>\n                    expression is increased compared with the rest of the adrenal cortex. We also show that many APCCs harbor known aldosterone-producing adenoma (APA)-related ion channels\/pumps (\n                    <jats:italic>ATPase, Na<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>\/K<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>transporting, \u03b11-polypeptide<\/jats:italic>\n                    and\n                    <jats:italic>calcium channel, voltage-dependent, L-type, \u03b11D-subunit<\/jats:italic>\n                    ) mutations that stimulate\n                    <jats:italic>CYP11B2<\/jats:italic>\n                    expression and aldosterone production. Importantly, the mutation spectrum seen in APCCs differs from that reported for APA. These results provide molecular support for APCC as a precursor of PA.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1505529112","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T22:49:47Z","timestamp":1438642187000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":302,"title":["Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands"],"prefix":"10.1073","volume":"112","author":[{"given":"Koshiro","family":"Nishimoto","sequence":"first","affiliation":[{"name":"Departments of Molecular and Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Tomlins","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Deparment of Urology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rork","family":"Kuick","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi K.","family":"Cani","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Hovelson","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Computational Medicine &amp; Bioinformatics, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aalok R.","family":"Sanjanwala","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Surgery, Temple University School of Medicine, Philadelphia, PA 19140;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso E.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, G. 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