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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Gains of the MYC gene are the most common imbalances in cancer and are associated with poor prognosis, particularly in B-cell lymphoma. Recent advances in DNA sequencing have revealed the existence of thousands of long noncoding RNAs (lncRNAs) with unknown functional relevance. We have here identified a MYC-regulated lncRNA that we named MYC-induced long noncoding RNA (MINCR) that has a strong correlation with MYC expression in cancer. We show that MINCR is functional and controls cell cycle progression by influencing the expression of MYC-regulated cell cycle genes. MINCR is, therefore, a novel player in MYC\u2019s transcriptional network, with the potential to open new therapeutic windows in the fight against malignant lymphoma and, possibly, all cancers that rely on MYC expression.<\/jats:p>","DOI":"10.1073\/pnas.1505753112","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T22:21:21Z","timestamp":1441750881000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":85,"title":["MINCR is a MYC-induced lncRNA able to modulate MYC\u2019s transcriptional network in Burkitt lymphoma cells"],"prefix":"10.1073","volume":"112","author":[{"given":"Gero","family":"Doose","sequence":"first","affiliation":[{"name":"Transcriptome Bioinformatics, Leipzig Research Center for Civilization Diseases, University of Leipzig, D-04107 Leipzig, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Haake","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University Hospital Schleswig-Holstein, Christian Albrechts University, D-24105 Kiel, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan H.","family":"Bernhart","sequence":"additional","affiliation":[{"name":"Transcriptome Bioinformatics, Leipzig Research Center for Civilization Diseases, University of Leipzig, D-04107 Leipzig, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University Hospital Schleswig-Holstein, Christian Albrechts University, D-24105 Kiel, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujitha","family":"Duggimpudi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, 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