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Using genomic binding profiles, methylation maps, and mRNA deep-sequencing data, we found MeCP2 binds to non-CG methylation (mCH, not mCG) to regulate expression of genes altered in mouse models of MeCP2 disorders. These data and the parallel timing of mCH and MeCP2 postnatal accumulation suggest MeCP2 binds mCH as neurons mature to regulate gene expression, offering an explanation for the delayed onset of Rett.<\/jats:p>","DOI":"10.1073\/pnas.1505909112","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T22:41:48Z","timestamp":1428964908000},"page":"5509-5514","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":304,"title":["MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome"],"prefix":"10.1073","volume":"112","author":[{"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Molecular and Human Genetics,"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Dan L. Duncan Cancer Center,"},{"name":"Department of Molecular and Cellular Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics,"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Andrew","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics,"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Dan L. Duncan Cancer Center,"},{"name":"Department of Molecular and Cellular Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda Y.","family":"Zoghbi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics,"},{"name":"Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030; and"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir RE","year":"1999","unstructured":"RE Amir, , Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. 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