{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:31:11Z","timestamp":1790476271636,"version":"4.1.0"},"reference-count":77,"publisher":"National Academy of Sciences","issue":"34","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["EY020950"],"award-info":[{"award-number":["EY020950"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["EY019885"],"award-info":[{"award-number":["EY019885"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["MHO88661-01"],"award-info":[{"award-number":["MHO88661-01"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,8,25]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Rett syndrome is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein 2 (\n                    <jats:italic>MeCP2<\/jats:italic>\n                    ). It is thought to result from altered neuronal connectivity and\/or plasticity, possibly through abnormal experience-dependent synapse development, but the underlying mechanisms remain obscure. Using\n                    <jats:italic>MeCP2<\/jats:italic>\n                    -null mice, we examined experience-dependent development of neural circuits in the primary visual cortex where GABAergic interneurons regulate a critical period of neural plasticity. We provide evidence that a precocious maturation of parvalbumin\n                    <jats:sup>+<\/jats:sup>\n                    GABAergic interneurons correlates with the altered timing of the critical period and deficient visual function in the absence of MECP2. Our study begins to establish a link from specific molecular changes in GABAergic neurons to critical period of circuit development and to functional alterations in a mouse model of Rett syndrome.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1506499112","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T22:30:34Z","timestamp":1439245834000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":151,"title":["MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex"],"prefix":"10.1073","volume":"112","author":[{"given":"Keerthi","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Shuen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Northwestern University, Evanston, IL 60208;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangteng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Wang","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Maffei","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Cang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Northwestern University, Evanston, IL 60208;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Josh","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90610-O"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.01.030"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.038"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3434"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.037"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12348"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089071"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.07.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10907"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10214"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07457"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.010261"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1787"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02108.1998"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81509-3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11356"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09582"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.004"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/85899"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506071102"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1851-04.2004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-10-03274.1996"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00729.2010"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072699"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","unstructured":"S Miyata Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat Neurosci 15(3):414\u2013422 S1-2. (2012).","DOI":"10.1038\/nn.3023"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06996.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1993.4500030709"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2006.09.006"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4812-10.2010"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077566"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2044"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061395"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192233099"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2890-08.2008"},{"key":"e_1_3_3_38_2","first-page":"65","article-title":"Developmental regulation of spatio-temporal patterns of cortical circuit activation","volume":"6","author":"Griffen TC","year":"2012","unstructured":"TC Griffen, L Wang, A Fontanini, A Maffei, Developmental regulation of spatio-temporal patterns of cortical circuit activation. Front Cell Neurosci 6, 65 (2012).","journal-title":"Front Cell Neurosci"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2012.00070"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.01.012"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/35004582"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.002"},{"key":"e_1_3_3_43_2","doi-asserted-by":"crossref","unstructured":"MS Lazarus K Krishnan ZJ Huang GAD67 deficiency in parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex . Cereb Cortex 25(5):1290\u20131296. (2013).","DOI":"10.1093\/cercor\/bht322"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2009.08.005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"crossref","unstructured":"W Jones A Klin Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism. Nature 504(7480):427\u2013431. (2013).","DOI":"10.1038\/nature12715"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113813"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.05.015"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12866"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.168211"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-21-06919.1996"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730698100"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001403200"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3002"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12911"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6655-10.2011"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.12.017"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255263"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.001"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn2008"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6036"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.023"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812394106"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.07.022"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20055"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.022"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.010"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10905"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-03-01834.1994"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2011.00012"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0623-08.2008"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00366"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225178"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2451-08.2008"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00286-1"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.011007"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22009"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1506499112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1506499112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:22:07Z","timestamp":1649809327000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1506499112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,10]]},"references-count":77,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2015,8,25]]}},"alternative-id":["10.1073\/pnas.1506499112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1506499112","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725713136.793511139","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725713136.793540757","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,10]]},"assertion":[{"value":"2015-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}