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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,6,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    This work identifies molecular factors produced by the fungus\n                    <jats:italic>Pseudogymnoascus destructans<\/jats:italic>\n                    , the causative agent of white-nose syndrome in bats. Our study reveals the repertoire of redox enzymes and hydrolytic enzymes secreted by\n                    <jats:italic>P. destructans<\/jats:italic>\n                    . We establish that a secreted serine peptidase, Destructin-1, is a major component of the\n                    <jats:italic>P. destructans<\/jats:italic>\n                    secretome. This peptidase was purified and shown to degrade collagen, the major structural protein in mammalian connective tissue. Furthermore, chemical inhibition of Destructin-1 blocked collagen degradation in conditioned media from\n                    <jats:italic>P. destructans<\/jats:italic>\n                    . We therefore propose that serine endopeptidases aid in invasive growth and tissue destruction by the fungus, and represent potential targets for therapeutic intervention in white-nose syndrome.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1507082112","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T22:32:20Z","timestamp":1430865140000},"page":"7478-7483","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":69,"title":["Destructin-1 is a collagen-degrading endopeptidase secreted by\n                    <i>Pseudogymnoascus destructans<\/i>\n                    , the causative agent of white-nose syndrome"],"prefix":"10.1073","volume":"112","author":[{"given":"Anthony J.","family":"O\u2019Donoghue","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle M.","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chapman","family":"Beekman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Brown University, Providence, RI 02912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna A.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Brown University, Providence, RI 02912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics,"},{"name":"Department of Microbiology and Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"DeRisi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics,"},{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94012; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Craik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Brown University, Providence, RI 02912"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"e1002779","DOI":"10.1371\/journal.ppat.1002779","article-title":"Fungal disease and the developing story of bat white-nose syndrome","volume":"8","author":"Blehert DS","year":"2012","unstructured":"DS Blehert, Fungal disease and the developing story of bat white-nose syndrome. 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