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U.S.A."],"published-print":{"date-parts":[[2015,10,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Most vaccines protect from infections by eliciting a long-lived antibody response. B-cell CLL\/lymphoma 6 (Bcl6) is a transcriptional repressor that is essential for the generation of long-lived antibody responses by promoting the differentiation of T follicular helper (Tfh) and germinal center B cells. Currently, the mechanisms by which Bcl6 directs Tfh cell differentiation is unclear. We show that mutations in the middle domain of Bcl6 prevent full differentiation of Tfh cells by loss of repression of key target genes. 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