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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>A successful HIV-1 vaccine should generate an immune response capable of neutralizing the enormous diversity of globally circulating viruses. Here, we report the discovery and characterization of two clade C recombinant envelope glycoprotein trimers with native-like structural and antigenic properties, including epitopes for all known classes of broadly neutralizing antibodies (bnAbs). Together with previously described trimers from other clades, these two new trimers will aid in immunization strategies designed to induce bnAbs to HIV-1.<\/jats:p>","DOI":"10.1073\/pnas.1507793112","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T22:21:21Z","timestamp":1441750881000},"page":"11947-11952","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":125,"title":["Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens"],"prefix":"10.1073","volume":"112","author":[{"given":"Jean-Philippe","family":"Julien","sequence":"first","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative ( IAVI) Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, Center for HIV\/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037;"},{"name":"Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada;"},{"name":"Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative ( IAVI) Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, Center for HIV\/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Ozorowski","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative ( IAVI) Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, Center for HIV\/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzi","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative ( IAVI) Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, Center for HIV\/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Torrents de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"de Taeye","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Nieusma","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative ( IAVI) Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, Center for HIV\/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Cupo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Yasmeen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Golabek","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Pugach","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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