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Female mice lacking GR specifically in the uterus are subfertile due to defects in implantation related to inadequate remodeling of the endometrial stroma. Moreover, the deficiency in uterine glucocorticoid signaling leads to aberrant gene regulation during tissue remodeling events. Our findings demonstrate previously unrecognized functions of GR in both uterine physiology and fertility.<\/jats:p>","DOI":"10.1073\/pnas.1508056112","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T22:19:00Z","timestamp":1448317140000},"page":"15166-15171","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization"],"prefix":"10.1073","volume":"112","author":[{"given":"Shannon D.","family":"Whirledge","sequence":"first","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Oakley","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Page H.","family":"Myers","sequence":"additional","affiliation":[{"name":"Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"DeMayo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Cidlowski","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3012"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1652"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.11.005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0720385"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.06.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.13.1608"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20098"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1074"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2014.966263"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00342-07"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-175349"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530162100"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.6.1784"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1099com"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.045336"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)47471-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46579-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03289.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/968141"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12289"},{"key":"e_1_3_3_21_2","first-page":"3954","article-title":"Uterine DCs are crucial for decidua formation during embryo implantation in mice","volume":"118","author":"Plaks V","year":"2008","unstructured":"V Plaks, , Uterine DCs are crucial for decidua formation during embryo implantation in mice. 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