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Although anti-TNF therapies are successful in controlling some inflammatory diseases, their cost and the development of resistance in some patients show that other treatment options are required. Our findings provide an important foundation toward understanding how\n                    <jats:italic>Tnf<\/jats:italic>\n                    expression is regulated and identify potential targets for therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1508399112","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T20:23:40Z","timestamp":1437423820000},"page":"9698-9703","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Spontaneous retrotransposon insertion into\n                    <i>TNF<\/i>\n                    3\u2032UTR causes heart valve disease and chronic polyarthritis"],"prefix":"10.1073","volume":"112","author":[{"given":"Derek","family":"Lacey","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;"},{"name":"Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hickey","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;"},{"name":"Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicta D.","family":"Arhatari","sequence":"additional","affiliation":[{"name":"Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Department of Physics, La Trobe University, VIC 3086, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine A.","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;"},{"name":"Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona","family":"Rohrbeck","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;"},{"name":"Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Kiriazis","sequence":"additional","affiliation":[{"name":"Baker IDI Heart and Diabetes Institute, and Central Clinical School, Monash University, Melbourne, VIC 3004, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Du","sequence":"additional","affiliation":[{"name":"Baker IDI Heart and Diabetes Institute, and Central Clinical School, Monash University, Melbourne, VIC 3004, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bouillet","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;"},{"name":"Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06075-5"},{"key":"e_1_3_3_2_2","first-page":"S43","article-title":"A systematic comparison of rheumatoid arthritis and ankylosing spondylitis","volume":"27","author":"van der Horst-Bruinsma IE","year":"2009","unstructured":"IE van der Horst-Bruinsma, WF Lems, BA Dijkmans, A systematic comparison of rheumatoid arthritis and ankylosing spondylitis. 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