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Binding creates a sharp kink of the duplex by 70\u00b0. Each protein inserts a hairpin loop into the duplex to induce partial melting around the lesion. The structures provide insight into the mechanism of how XPA binds to kinked and lesion-containing DNA.<\/jats:p>","DOI":"10.1073\/pnas.1508509112","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T22:01:34Z","timestamp":1435010494000},"page":"8272-8277","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)"],"prefix":"10.1073","volume":"112","author":[{"given":"Sandra C.","family":"Koch","sequence":"first","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Kuper","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of W\u00fcrzburg, 97080 Wurzburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karola L.","family":"Gasteiger","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Simon","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Strasser","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eisen","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Geiger","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Technische Universit\u00e4t M\u00fcnchen, 85747 Garching, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kisker","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of W\u00fcrzburg, 97080 Wurzburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Carell","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,6,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0923-1811(99)00088-2","article-title":"Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum","volume":"23","author":"Cleaver JE","year":"2000","unstructured":"JE Cleaver, Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum. 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