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HAX-1 works through recruitment of a chaperone protein called Hsp90 from cyclophilin-D, a major component of the pore. Displacement of Hsp90 from cyclophilin-D promotes cyclophilin-D degradation, resulting in inhibition of pore opening and cell death. Given that the opening of the mitochondrial permeability transition pore contributes to various diseases, our findings have broader applications reaching beyond the heart.<\/jats:p>","DOI":"10.1073\/pnas.1508760112","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T23:14:28Z","timestamp":1447110868000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart"],"prefix":"10.1073","volume":"112","author":[{"given":"Chi Keung","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Feng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Adly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia G.","family":"Kranias","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301863"},{"key":"e_1_3_3_2_2","first-page":"213","article-title":"Mitochondria and heart failure: New insights into an energetic problem","volume":"58","author":"Chen L","year":"2010","unstructured":"L Chen, AA Knowlton, Mitochondria and heart failure: New insights into an energetic problem. 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