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We here identify a singular process comprising a network of cascading chemical reactions that form three main bioactive products at physiological pH: nitrosopersulfide, polysulfides, and dinitrososulfite. These anionic products scavenge, transport, and release NO\/HNO or sulfide\/sulfane sulfur, each displaying distinct chemistries and bioactivities. Our observations provide a chemical foundation for the cross-talk between the NO and H\n                    <jats:sub>2<\/jats:sub>\n                    S signaling pathways in biology and suggest that the biological actions of these entities can be neither considered nor studied in isolation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1509277112","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T23:24:43Z","timestamp":1438212283000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":253,"title":["Key bioactive reaction products of the NO\/H\n                    <sub>2<\/sub>\n                    S interaction are S\/N-hybrid species, polysulfides, and nitroxyl"],"prefix":"10.1073","volume":"112","author":[{"given":"Miriam M.","family":"Cortese-Krott","sequence":"first","affiliation":[{"name":"Cardiovascular Research Laboratory, Department of Cardiology, Pneumology and Angiology, Medical Faculty, Heinrich Heine University of D\u00fcsseldorf, 40225 Dusseldorf, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter G. 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Bruce","family":"King","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research, Inc., National Cancer Institute\u2013Frederick, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry K.","family":"Keefer","sequence":"additional","affiliation":[{"name":"National Cancer Institute\u2013Frederick, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Singer","sequence":"additional","affiliation":[{"name":"Bloomsbury Institute of Intensive Care Medicine, University College London, London WC1E 6BT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory, Department of Cardiology, Pneumology and Angiology, Medical Faculty, Heinrich Heine University of D\u00fcsseldorf, 40225 Dusseldorf, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Butler","sequence":"additional","affiliation":[{"name":"Medical School, University of St. Andrews, St. Andrews, Fife KY16 9AJ, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital and Institute for Life Sciences, Southampton SO16 6YD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.38.4.351"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(00)89206-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-012-0654-y"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019191108"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2202"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7407com"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-8-30"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P"},{"key":"e_1_3_3_9_2","first-page":"189","article-title":"Reaction of sulfides with nitrogen monoxide in aqueous solution","volume":"558","author":"Seel F","year":"1988","unstructured":"F Seel, M Wagner, Reaction of sulfides with nitrogen monoxide in aqueous solution. 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