{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:49:53Z","timestamp":1793382593402,"version":"4.5.0"},"reference-count":84,"publisher":"National Academy of Sciences","issue":"25","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA22443"],"award-info":[{"award-number":["CA22443"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,6,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Cervical cancer (CxCa) is the second most frequent cancer in women and the third leading cause of cancer death in women worldwide. Our global analysis of gene expression in normal, precancerous, and cancerous cervical tissue shows increased DNA replication\/repair and cell proliferation followed by substantial metabolic shifts. We observed a dramatic, progressive decrease in estrogen receptor alpha (ER\u03b1) in tumor progression, and ranking specimens by estrogen-responsive gene expression correlated remarkably with histopathology. Whereas ER\u03b1 expression shuts off in tumor epithelium, stromal fibroblasts in the microenvironment retain ER\u03b1, and the data indicate estrogen-related alteration of several candidate stroma\u2013tumor signaling pathways. Our findings strongly support a role of stromal estrogen signaling in CxCa development with implications for CxCa management and control.<\/jats:p>","DOI":"10.1073\/pnas.1509322112","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T13:23:59Z","timestamp":1433942639000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":212,"title":["Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling"],"prefix":"10.1073","volume":"112","author":[{"given":"Johan A.","family":"den Boon","sequence":"first","affiliation":[{"name":"Morgridge Institute for Research, University of Wisconsin\u2013Madison, Madison, WI 53715;"},{"name":"McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, WI 53792;"},{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohun","family":"Pyeon","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO 80045;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Horswill","sequence":"additional","affiliation":[{"name":"Morgridge Institute for Research, University of Wisconsin\u2013Madison, Madison, WI 53715;"},{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary E.","family":"Zuna","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pearson","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706;"},{"name":"Howard Hughes Medical Institute, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Schott","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, WI 53792;"},{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lambert","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, WI 53792;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Walker","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Newton","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Wisconsin\u2013Madison, Madison, WI 53706;"},{"name":"Department of Biostatistics and Medical Informatics, University of Wisconsin\u2013Madison, Madison, WI 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ahlquist","sequence":"additional","affiliation":[{"name":"Morgridge Institute for Research, University of Wisconsin\u2013Madison, Madison, WI 53715;"},{"name":"McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, WI 53792;"},{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706;"},{"name":"Howard Hughes Medical Institute, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"World Health Organization (2015) Human papillomavirus (HPV) and cervical cancer Fact Sheet No 380. Available at www.who.int\/mediacentre\/factsheets\/fs380\/en\/. Accessed May 26 2015."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1470-2045(14)70073-7","article-title":"Filling a gap in cervical cancer screening programmes","volume":"15","author":"Wentzensen N","year":"2014","unstructured":"N Wentzensen, M Schiffman, Filling a gap in cervical cancer screening programmes. Lancet Oncol 15, 249\u2013251 (2014).","journal-title":"Lancet Oncol"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/1055-9965.EPI-12-1406","article-title":"Human papillomavirus infection and the multistage carcinogenesis of cervical cancer","volume":"22","author":"Schiffman M","year":"2013","unstructured":"M Schiffman, N Wentzensen, Human papillomavirus infection and the multistage carcinogenesis of cervical cancer. Cancer Epidemiol Biomarkers Prev 22, 553\u2013560 (2013).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan D","year":"2011","unstructured":"D Hanahan, RA Weinberg, Hallmarks of cancer: The next generation. Cell 144, 646\u2013674 (2011).","journal-title":"Cell"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.virol.2008.11.046","article-title":"Papillomaviruses in the causation of human cancers\u2014A brief historical account","volume":"384","author":"zur Hausen H","year":"2009","unstructured":"H zur Hausen, Papillomaviruses in the causation of human cancers\u2014A brief historical account. Virology 384, 260\u2013265 (2009).","journal-title":"Virology"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers JM","year":"1999","unstructured":"JM Walboomers, , Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189, 12\u201319 (1999).","journal-title":"J Pathol"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.ygyno.2010.01.024","article-title":"Pathology and epidemiology of HPV infection in females","volume":"117","author":"Stanley M","year":"2010","unstructured":"M Stanley, Pathology and epidemiology of HPV infection in females. Gynecol Oncol 117, S5\u2013S10 (2010).","journal-title":"Gynecol Oncol"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.virol.2008.11.017","article-title":"Papillomavirus E6 proteins","volume":"384","author":"Howie HL","year":"2009","unstructured":"HL Howie, RA Katzenellenbogen, DA Galloway, Papillomavirus E6 proteins. Virology 384, 324\u2013334 (2009).","journal-title":"Virology"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.virol.2006.08.028","article-title":"Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle","volume":"358","author":"Lee C","year":"2007","unstructured":"C Lee, TR Wooldridge, LA Laimins, Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. Virology 358, 201\u2013210 (2007).","journal-title":"Virology"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1128\/JVI.73.9.7297-7307.1999","article-title":"Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells","volume":"73","author":"Liu Y","year":"1999","unstructured":"Y Liu, , Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J Virol 73, 7297\u20137307 (1999).","journal-title":"J Virol"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2008.10.006","article-title":"The human papillomavirus E7 oncoprotein","volume":"384","author":"McLaughlin-Drubin ME","year":"2009","unstructured":"ME McLaughlin-Drubin, K M\u00fcnger, The human papillomavirus E7 oncoprotein. Virology 384, 335\u2013344 (2009).","journal-title":"Virology"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2886","article-title":"Human papillomavirus oncoproteins: Pathways to transformation","volume":"10","author":"Moody CA","year":"2010","unstructured":"CA Moody, LA Laimins, Human papillomavirus oncoproteins: Pathways to transformation. Nat Rev Cancer 10, 550\u2013560 (2010).","journal-title":"Nat Rev Cancer"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1128\/JVI.78.21.11451-11460.2004","article-title":"Mechanisms of human papillomavirus-induced oncogenesis","volume":"78","author":"M\u00fcnger K","year":"2004","unstructured":"K M\u00fcnger, , Mechanisms of human papillomavirus-induced oncogenesis. J Virol 78, 11451\u201311460 (2004).","journal-title":"J Virol"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/jnci\/djn044","article-title":"Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections","volume":"100","author":"Rodr\u00edguez AC","year":"2008","unstructured":"AC Rodr\u00edguez, , Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. J Natl Cancer Inst; Proyecto Epidemiol\u00f3gico Guanacaste Group 100, 513\u2013517 (2008).","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1158\/1055-9965.EPI-08-0591","article-title":"Human papillomavirus cofactors by disease progression and human papillomavirus types in the Study to Understand Cervical Cancer Early Endpoints and Determinants","volume":"18","author":"Wang SS","year":"2009","unstructured":"SS Wang, , Human papillomavirus cofactors by disease progression and human papillomavirus types in the Study to Understand Cervical Cancer Early Endpoints and Determinants. Cancer Epidemiol Biomarkers Prev 18, 113\u2013120 (2009).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ygyno.2012.11.003","article-title":"The role of co-factors in the progression from human papillomavirus infection to cervical cancer","volume":"128","author":"Luhn P","year":"2013","unstructured":"P Luhn, , The role of co-factors in the progression from human papillomavirus infection to cervical cancer. Gynecol Oncol 128, 265\u2013270 (2013).","journal-title":"Gynecol Oncol"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1073\/pnas.93.7.2930","article-title":"Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice","volume":"93","author":"Arbeit JM","year":"1996","unstructured":"JM Arbeit, PM Howley, D Hanahan, Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci USA 93, 2930\u20132935 (1996).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.1158\/0008-5472.CAN-08-2051","article-title":"Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer","volume":"68","author":"Chung SH","year":"2008","unstructured":"SH Chung, K Wiedmeyer, A Shai, KS Korach, PF Lambert, Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res 68, 9928\u20139934 (2008).","journal-title":"Cancer Res"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.tem.2010.03.005","article-title":"Estrogen and ERalpha: Culprits in cervical cancer?","volume":"21","author":"Chung SH","year":"2010","unstructured":"SH Chung, S Franceschi, PF Lambert, Estrogen and ERalpha: Culprits in cervical cancer? Trends Endocrinol Metab 21, 504\u2013511 (2010).","journal-title":"Trends Endocrinol Metab"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"19467","DOI":"10.1073\/pnas.0911436106","article-title":"Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists","volume":"106","author":"Chung SH","year":"2009","unstructured":"SH Chung, PF Lambert, Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists. Proc Natl Acad Sci USA 106, 19467\u201319472 (2009).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"11164","DOI":"10.1158\/0008-5472.CAN-05-1087","article-title":"Induction of aromatase expression in cervical carcinomas: Effects of endogenous estrogen on cervical cancer cell proliferation","volume":"65","author":"Nair HB","year":"2005","unstructured":"HB Nair, , Induction of aromatase expression in cervical carcinomas: Effects of endogenous estrogen on cervical cancer cell proliferation. Cancer Res 65, 11164\u201311173 (2005).","journal-title":"Cancer Res"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1158\/0008-5472.CAN-06-3619","article-title":"Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head\/neck and cervical cancers","volume":"67","author":"Pyeon D","year":"2007","unstructured":"D Pyeon, , Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head\/neck and cervical cancers. Cancer Res 67, 4605\u20134619 (2007).","journal-title":"Cancer Res"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1158\/1055-9965.EPI-08-0306","article-title":"Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia","volume":"17","author":"Cuschieri K","year":"2008","unstructured":"K Cuschieri, N Wentzensen, Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev 17, 2536\u20132545 (2008).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.1174","article-title":"Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","volume":"92","author":"Klaes R","year":"2001","unstructured":"R Klaes, , Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92, 276\u2013284 (2001).","journal-title":"Int J Cancer"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0002-9440(10)65689-1","article-title":"Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions","volume":"153","author":"Sano T","year":"1998","unstructured":"T Sano, T Oyama, K Kashiwabara, T Fukuda, T Nakajima, Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 153, 1741\u20131748 (1998).","journal-title":"Am J Pathol"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1155\/2007\/678793","article-title":"Biomarkers in cervical cancer screening","volume":"23","author":"Wentzensen N","year":"2007","unstructured":"N Wentzensen, M von Knebel Doeberitz, Biomarkers in cervical cancer screening. Dis Markers 23, 315\u2013330 (2007).","journal-title":"Dis Markers"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2008.06.016","article-title":"A mitochondrial protein compendium elucidates complex I disease biology","volume":"134","author":"Pagliarini DJ","year":"2008","unstructured":"DJ Pagliarini, , A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112\u2013123 (2008).","journal-title":"Cell"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccr.2012.02.014","article-title":"Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate","volume":"21","author":"Ward PS","year":"2012","unstructured":"PS Ward, CB Thompson, Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate. Cancer Cell 21, 297\u2013308 (2012).","journal-title":"Cancer Cell"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: Warburg and beyond","volume":"134","author":"Hsu PP","year":"2008","unstructured":"PP Hsu, DM Sabatini, Cancer cell metabolism: Warburg and beyond. Cell 134, 703\u2013707 (2008).","journal-title":"Cell"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.nutr.012809.104810","article-title":"Compartmentalization of mammalian folate-mediated one-carbon metabolism","volume":"30","author":"Tibbetts AS","year":"2010","unstructured":"AS Tibbetts, DR Appling, Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30, 57\u201381 (2010).","journal-title":"Annu Rev Nutr"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1749-6632.2000.tb06649.x","article-title":"Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging","volume":"908","author":"Melov S","year":"2000","unstructured":"S Melov, Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging. Ann N Y Acad Sci 908, 219\u2013225 (2000).","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"D533","DOI":"10.1093\/nar\/gkh083","article-title":"ERGDB: Estrogen Responsive Genes Database","volume":"32","author":"Tang S","year":"2004","unstructured":"S Tang, H Han, VB Bajic, ERGDB: Estrogen Responsive Genes Database. Nucleic Acids Res 32, D533\u2013D536 (2004).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0145-2126(85)90082-7","article-title":"Identification of a membrane glycoprotein associated with haemopoietic progenitor cells","volume":"9","author":"Katz FE","year":"1985","unstructured":"FE Katz, R Tindle, DR Sutherland, MF Greaves, Identification of a membrane glycoprotein associated with haemopoietic progenitor cells. Leuk Res 9, 191\u2013198 (1985).","journal-title":"Leuk Res"},{"key":"e_1_3_4_34_2","first-page":"141","article-title":"Monocyte\/macrophage-reactive monoclonal antibody Ki-M6 recognizes an intracytoplasmic antigen","volume":"125","author":"Parwaresch MR","year":"1986","unstructured":"MR Parwaresch, HJ Radzun, H Kreipe, ML Hansmann, J Barth, Monocyte\/macrophage-reactive monoclonal antibody Ki-M6 recognizes an intracytoplasmic antigen. Am J Pathol 125, 141\u2013151 (1986).","journal-title":"Am J Pathol"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.iy.12.040194.000505","article-title":"CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development","volume":"12","author":"Trowbridge IS","year":"1994","unstructured":"IS Trowbridge, ML Thomas, CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu Rev Immunol 12, 85\u2013116 (1994).","journal-title":"Annu Rev Immunol"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1083\/jcb.103.6.2787","article-title":"A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation","volume":"103","author":"Skalli O","year":"1986","unstructured":"O Skalli, , A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation. J Cell Biol 103, 2787\u20132796 (1986).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.bi.57.070188.003113","article-title":"Molecular and cellular biology of intermediate filaments","volume":"57","author":"Steinert PM","year":"1988","unstructured":"PM Steinert, DR Roop, Molecular and cellular biology of intermediate filaments. Annu Rev Biochem 57, 593\u2013625 (1988).","journal-title":"Annu Rev Biochem"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1158\/0008-5472.CAN-07-2056","article-title":"Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion","volume":"67","author":"Zhai Y","year":"2007","unstructured":"Y Zhai, , Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res 67, 10163\u201310172 (2007).","journal-title":"Cancer Res"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1158\/0008-5472.CAN-07-0260","article-title":"Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates","volume":"67","author":"Gius D","year":"2007","unstructured":"D Gius, , Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates. Cancer Res 67, 7113\u20137123 (2007).","journal-title":"Cancer Res"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/gcc.20590","article-title":"Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer","volume":"47","author":"Wilting SM","year":"2008","unstructured":"SM Wilting, , Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer. Genes Chromosomes Cancer 47, 890\u2013905 (2008).","journal-title":"Genes Chromosomes Cancer"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2407-11-80","article-title":"Identification and validation of genes involved in cervical tumourigenesis","volume":"11","author":"Rajkumar T","year":"2011","unstructured":"T Rajkumar, , Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer 11, 80 (2011).","journal-title":"BMC Cancer"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"10516","DOI":"10.1073\/pnas.1202684109","article-title":"A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer","volume":"109","author":"Herfs M","year":"2012","unstructured":"M Herfs, , A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci USA 109, 10516\u201310521 (2012).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1038\/sj.onc.1205709","article-title":"Human papillomaviruses and centrosome duplication errors: Modeling the origins of genomic instability","volume":"21","author":"Duensing S","year":"2002","unstructured":"S Duensing, K M\u00fcnger, Human papillomaviruses and centrosome duplication errors: Modeling the origins of genomic instability. Oncogene 21, 6241\u20136248 (2002).","journal-title":"Oncogene"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1086\/595563","article-title":"Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer","volume":"199","author":"Wang SS","year":"2009","unstructured":"SS Wang, , Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. J Infect Dis 199, 20\u201330 (2009).","journal-title":"J Infect Dis"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/jnci\/djg091","article-title":"Human papillomavirus DNA and p53 polymorphisms in squamous cell carcinomas from Fanconi anemia patients","volume":"95","author":"Kutler DI","year":"2003","unstructured":"DI Kutler, , Human papillomavirus DNA and p53 polymorphisms in squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst 95, 1718\u20131721 (2003).","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1093\/jnci\/djg125","article-title":"A new link between Fanconi anemia and human papillomavirus-associated malignancies","volume":"95","author":"Lowy DR","year":"2003","unstructured":"DR Lowy, ML Gillison, A new link between Fanconi anemia and human papillomavirus-associated malignancies. J Natl Cancer Inst 95, 1648\u20131650 (2003).","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.1158\/0008-5472.CAN-10-1291","article-title":"Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer","volume":"70","author":"Park JW","year":"2010","unstructured":"JW Park, , Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res 70, 9959\u20139968 (2010).","journal-title":"Cancer Res"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"13265","DOI":"10.1128\/JVI.01121-07","article-title":"The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells","volume":"81","author":"Spardy N","year":"2007","unstructured":"N Spardy, , The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J Virol 81, 13265\u201313270 (2007).","journal-title":"J Virol"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.virol.2009.02.036","article-title":"Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses","volume":"387","author":"Nakamura M","year":"2009","unstructured":"M Nakamura, , Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses. Virology 387, 442\u2013448 (2009).","journal-title":"Virology"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1158\/1078-0432.CCR-06-2704","article-title":"Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells","volume":"13","author":"Tang X","year":"2007","unstructured":"X Tang, , Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. Clin Cancer Res 13, 2568\u20132576 (2007).","journal-title":"Clin Cancer Res"},{"key":"e_1_3_4_51_2","doi-asserted-by":"crossref","first-page":"12444","DOI":"10.1073\/pnas.1302140110","article-title":"A mechanism for induction of a hypoxic response by vaccinia virus","volume":"110","author":"Mazzon M","year":"2013","unstructured":"M Mazzon, , A mechanism for induction of a hypoxic response by vaccinia virus. Proc Natl Acad Sci USA 110, 12444\u201312449 (2013).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_52_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate\u2019s role","volume":"3","author":"Crider KS","year":"2012","unstructured":"KS Crider, TP Yang, RJ Berry, LB Bailey, Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate\u2019s role. Adv Nutr 3, 21\u201338 (2012).","journal-title":"Adv Nutr"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3945\/jn.109.113670","article-title":"One-carbon metabolism-genome interactions in folate-associated pathologies","volume":"139","author":"Stover PJ","year":"2009","unstructured":"PJ Stover, One-carbon metabolism-genome interactions in folate-associated pathologies. J Nutr 139, 2402\u20132405 (2009).","journal-title":"J Nutr"},{"key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.3390\/ijms12107114","article-title":"Manganese superoxide dismutase: Guardian of the powerhouse","volume":"12","author":"Holley AK","year":"2011","unstructured":"AK Holley, V Bakthavatchalu, JM Velez-Roman, DK St Clair, Manganese superoxide dismutase: Guardian of the powerhouse. Int J Mol Sci 12, 7114\u20137162 (2011).","journal-title":"Int J Mol Sci"},{"key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"E139","DOI":"10.1371\/journal.pbio.0020139","article-title":"Many ribosomal protein genes are cancer genes in zebrafish","volume":"2","author":"Amsterdam A","year":"2004","unstructured":"A Amsterdam, , Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol 2, E139 (2004).","journal-title":"PLoS Biol"},{"key":"e_1_3_4_56_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","article-title":"c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells","volume":"151","author":"Nie Z","year":"2012","unstructured":"Z Nie, , c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 151, 68\u201379 (2012).","journal-title":"Cell"},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc2819","article-title":"MYC as a regulator of ribosome biogenesis and protein synthesis","volume":"10","author":"van Riggelen J","year":"2010","unstructured":"J van Riggelen, A Yetil, DW Felsher, MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 10, 301\u2013309 (2010).","journal-title":"Nat Rev Cancer"},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0140-6736(07)61684-5","article-title":"Cervical cancer and hormonal contraceptives: Collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies","volume":"370","author":"Appleby P","year":"2007","unstructured":"P Appleby, , Cervical cancer and hormonal contraceptives: Collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet; International Collaboration of Epidemiological Studies of Cervical Cancer 370, 1609\u20131621 (2007).","journal-title":"Lancet"},{"key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2353\/ajpath.2010.091166","article-title":"Loss of estrogen receptor 1 enhances cervical cancer invasion","volume":"177","author":"Zhai Y","year":"2010","unstructured":"Y Zhai, , Loss of estrogen receptor 1 enhances cervical cancer invasion. Am J Pathol 177, 884\u2013895 (2010).","journal-title":"Am J Pathol"},{"key":"e_1_3_4_60_2","first-page":"153","article-title":"Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas","volume":"26","author":"Kwasniewska A","year":"2011","unstructured":"A Kwasniewska, , Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas. Oncol Rep 26, 153\u2013160 (2011).","journal-title":"Oncol Rep"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s12672-012-0125-7","article-title":"Requirement for stromal estrogen receptor alpha in cervical neoplasia","volume":"4","author":"Chung SH","year":"2013","unstructured":"SH Chung, MK Shin, KS Korach, PF Lambert, Requirement for stromal estrogen receptor alpha in cervical neoplasia. Horm Cancer 4, 50\u201359 (2013).","journal-title":"Horm Cancer"},{"key":"e_1_3_4_62_2","first-page":"482","article-title":"Cancer associated fibroblasts: The dark side of the coin","volume":"1","author":"Cirri P","year":"2011","unstructured":"P Cirri, P Chiarugi, Cancer associated fibroblasts: The dark side of the coin. Am J Cancer Res 1, 482\u2013497 (2011).","journal-title":"Am J Cancer Res"},{"key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/v5051231","article-title":"Biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins","volume":"5","author":"McLaughlin-Drubin ME","year":"2013","unstructured":"ME McLaughlin-Drubin, K Munger, Biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins. Viruses 5, 1231\u20131249 (2013).","journal-title":"Viruses"},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0301-2115(98)00117-1","article-title":"Tamoxifen and proliferation of vaginal and cervical epithelium in postmenopausal women with breast cancer","volume":"80","author":"Friedrich M","year":"1998","unstructured":"M Friedrich, D Mink, C Villena-Heinsen, A Woll-Hermann, W Schmidt, Tamoxifen and proliferation of vaginal and cervical epithelium in postmenopausal women with breast cancer. Eur J Obstet Gynecol Reprod Biol 80, 221\u2013225 (1998).","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"e_1_3_4_65_2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1210\/me.2002-0438","article-title":"Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells","volume":"17","author":"Hall JM","year":"2003","unstructured":"JM Hall, KS Korach, Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol 17, 792\u2013803 (2003).","journal-title":"Mol Endocrinol"},{"key":"e_1_3_4_66_2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.chom.2010.11.006","article-title":"A pivotal role for CXCL12 signaling in HPV-mediated transformation of keratinocytes: Clues to understanding HPV-pathogenesis in WHIM syndrome","volume":"8","author":"Chow KY","year":"2010","unstructured":"KY Chow, , A pivotal role for CXCL12 signaling in HPV-mediated transformation of keratinocytes: Clues to understanding HPV-pathogenesis in WHIM syndrome. Cell Host Microbe 8, 523\u2013533 (2010).","journal-title":"Cell Host Microbe"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh DJ","year":"2008","unstructured":"DJ Waugh, C Wilson, The interleukin-8 pathway in cancer. Clin Cancer Res 14, 6735\u20136741 (2008).","journal-title":"Clin Cancer Res"},{"key":"e_1_3_4_68_2","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1158\/0008-5472.CAN-11-0156","article-title":"IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells","volume":"71","author":"Fernando RI","year":"2011","unstructured":"RI Fernando, MD Castillo, M Litzinger, DH Hamilton, C Palena, IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res 71, 5296\u20135306 (2011).","journal-title":"Cancer Res"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2217\/fon.12.59","article-title":"Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment","volume":"8","author":"Palena C","year":"2012","unstructured":"C Palena, DH Hamilton, RI Fernando, Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. Future Oncol 8, 713\u2013722 (2012).","journal-title":"Future Oncol"},{"key":"e_1_3_4_70_2","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1126\/science.1281554","article-title":"Interleukin-8 as a macrophage-derived mediator of angiogenesis","volume":"258","author":"Koch AE","year":"1992","unstructured":"AE Koch, , Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258, 1798\u20131801 (1992).","journal-title":"Science"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1600-0463.2004.apm11207-0808.x","article-title":"The chemokine system\u2014A major regulator of angiogenesis in health and disease","volume":"112","author":"Rosenkilde MM","year":"2004","unstructured":"MM Rosenkilde, TW Schwartz, The chemokine system\u2014A major regulator of angiogenesis in health and disease. APMIS 112, 481\u2013495 (2004).","journal-title":"APMIS"},{"key":"e_1_3_4_72_2","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1158\/0008-5472.CAN-06-3505","article-title":"Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells","volume":"67","author":"Zhao C","year":"2007","unstructured":"C Zhao, , Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res 67, 3955\u20133962 (2007).","journal-title":"Cancer Res"},{"key":"e_1_3_4_73_2","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1158\/0008-5472.CAN-11-3768","article-title":"Stromal estrogen receptor-\u03b1 promotes tumor growth by normalizing an increased angiogenesis","volume":"72","author":"P\u00e9queux C","year":"2012","unstructured":"C P\u00e9queux, , Stromal estrogen receptor-\u03b1 promotes tumor growth by normalizing an increased angiogenesis. Cancer Res 72, 3010\u20133019 (2012).","journal-title":"Cancer Res"},{"key":"e_1_3_4_74_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/sj.onc.1206113","article-title":"IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells","volume":"22","author":"Freund A","year":"2003","unstructured":"A Freund, , IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene 22, 256\u2013265 (2003).","journal-title":"Oncogene"},{"key":"e_1_3_4_75_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3109\/10715762.2010.490836","article-title":"Reactive oxygen species (ROS) reduce the expression of BRAK\/CXCL14 in human head and neck squamous cell carcinoma cells","volume":"44","author":"Maehata Y","year":"2010","unstructured":"Y Maehata, , Reactive oxygen species (ROS) reduce the expression of BRAK\/CXCL14 in human head and neck squamous cell carcinoma cells. Free Radic Res 44, 913\u2013924 (2010).","journal-title":"Free Radic Res"},{"key":"e_1_3_4_76_2","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: Open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman RC","year":"2004","unstructured":"RC Gentleman, , Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol 5, R80 (2004).","journal-title":"Genome Biol"},{"key":"e_1_3_4_77_2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A model-based background adjustment for oligonucleotide expression arrays","volume":"99","author":"Wu ZJ","year":"2004","unstructured":"ZJ Wu, RA Irizarry, R Gentleman, F Martinez-Murillo, F Spencer, A model-based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 99, 909\u2013917 (2004).","journal-title":"J Am Stat Assoc"},{"key":"e_1_3_4_78_2","first-page":"1406.5823","article-title":"Fitting linear mixed-effects models using lme4","author":"Bates D","year":"2014","unstructured":"D Bates, M M\u00e4chler, BM Bolker, SC Walker, Fitting linear mixed-effects models using lme4. J Stat Softw arXiv, 1406.5823 (2014).","journal-title":"J Stat Softw"},{"key":"e_1_3_4_79_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Y Benjamini, Y Hochberg, Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological) 57, 289\u2013300 (1995).","journal-title":"Journal of the Royal Statistical Society. Series B (Methodological)"},{"key":"e_1_3_4_80_2","first-page":"1724","article-title":"Capturing heterogeneity in gene expression studies by surrogate variable analysis","volume":"3","author":"Leek JT","year":"2007","unstructured":"JT Leek, JD Storey, Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet 3, 1724\u20131735 (2007).","journal-title":"PLoS Genet"},{"key":"e_1_3_4_81_2","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1002\/sim.1548","article-title":"On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles","volume":"22","author":"Kendziorski CM","year":"2003","unstructured":"CM Kendziorski, MA Newton, H Lan, MN Gould, On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles. Stat Med 22, 3899\u20133914 (2003).","journal-title":"Stat Med"},{"key":"e_1_3_4_82_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: Tool for the unification of biology","volume":"25","author":"Ashburner M","year":"2000","unstructured":"M Ashburner, , Gene Ontology: Tool for the unification of biology. Nat Genet; The Gene Ontology Consortium 25, 25\u201329 (2000).","journal-title":"Nat Genet"},{"key":"e_1_3_4_83_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1214\/07-AOAS104","article-title":"Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis","volume":"1","author":"Newton MA","year":"2007","unstructured":"MA Newton, FA Quintana, JA den Boon, S Sengupta, P Ahlquist, Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis. Ann Appl Stat 1, 85\u2013106 (2007).","journal-title":"Ann Appl Stat"},{"key":"e_1_3_4_84_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"R: A language for data analysis and graphics","volume":"5","author":"Ihaka R","year":"1996","unstructured":"R Ihaka, R Gentleman, R: A language for data analysis and graphics. J Comput Graph Stat 5, 299\u2013314 (1996).","journal-title":"J Comput Graph Stat"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1509322112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1509322112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T08:06:43Z","timestamp":1717920403000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1509322112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":84,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2015,6,23]]}},"alternative-id":["10.1073\/pnas.1509322112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1509322112","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725544916.793509087","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725544916.793510942","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]},"assertion":[{"value":"2015-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}