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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,10,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Genome sequence analysis reveals that the zoonotic malaria parasite\n                    <jats:italic>Plasmodium knowlesi<\/jats:italic>\n                    consists of three highly divergent subpopulations. Two, commonly seen in sympatric human clinical infections in Malaysian Borneo, were identified in a previous study as corresponding to parasites seen in long-tailed and pig-tailed macaque hosts, respectively. A third type has been detected in a few laboratory-maintained isolates originally derived in the 1960s elsewhere in Southeast Asia. Divergence between the subpopulations varies significantly across the genome but overall is at a level indicating different subspecies. Analysis of the diversity within the most common type in human infections shows strong signatures of natural selection, including balancing selection and directional selection, on loci distinct from those under selection in endemic human malaria parasites.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1509534112","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T22:58:48Z","timestamp":1444085928000},"page":"13027-13032","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["Population genomic structure and adaptation in the zoonotic malaria parasite\n                    <i>Plasmodium knowlesi<\/i>"],"prefix":"10.1073","volume":"112","author":[{"given":"Samuel","family":"Assefa","sequence":"first","affiliation":[{"name":"Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, WC1E 7HT United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caeul","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T. 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