{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:34:32Z","timestamp":1791246872958,"version":"4.1.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["5T32DA007281-17"],"award-info":[{"award-number":["5T32DA007281-17"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["5T32EY017878-10"],"award-info":[{"award-number":["5T32EY017878-10"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"DOD | Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-15-1-2224"],"award-info":[{"award-number":["N00014-15-1-2224"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"DOD | Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-12-1-0366"],"award-info":[{"award-number":["N00014-12-1-0366"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH104261"],"award-info":[{"award-number":["R01MH104261"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Molecular mechanisms mediating negative emotion and contributing to major depression remain elusive: here, we present evidence implicating fibroblast growth factor 9 (FGF9) as a key mediator. We use whole-transcriptome studies of postmortem human tissue to demonstrate that FGF9 is elevated in depression. Reverse translation animal studies demonstrate that both endogenous and exogenous FGF9 promotes anxiety- and depression-like behavior. Conversely, localized blockade of endogenous FGF9 expression decreases anxiety behavior. To our knowledge, this paper is the first description of hippocampal FGF9 function and the first evidence implicating FGF9 in negative affect. Thus, FGF9 represents a novel target for treating affective disorders. Moreover, our findings suggest that FGF2 and FGF9 work in functional opposition; we hypothesize that the balance between FGF factors may prove critical for optimal regulation of mood.<\/jats:p>","DOI":"10.1073\/pnas.1510456112","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T22:21:21Z","timestamp":1441750881000},"page":"11953-11958","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":58,"title":["Fibroblast growth factor 9 is a novel modulator of negative affect"],"prefix":"10.1073","volume":"112","author":[{"given":"Elyse L.","family":"Aurbach","sequence":"first","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edny Gula","family":"Inui","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cortney A.","family":"Turner","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan H.","family":"Hagenauer","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Prater","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Z.","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Absher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Human Behavior, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmul","family":"Shah","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Peter","family":"Blandino","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Bunney","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Human Behavior, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Myers","sequence":"additional","affiliation":[{"name":"HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack D.","family":"Barchas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Cornell University, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan F.","family":"Schatzberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Stanford University, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Stanley J.","family":"Watson","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda","family":"Akil","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.037"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406788101"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.44"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.04.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.10.041"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.088"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.03.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.5.1017"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00342-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4829-08.2009"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103732108"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.11.020"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.05.003"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00009-H"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)13312-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01340-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000401)60:1<1::AID-JNR1>3.0.CO;2-P"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.02.011"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199910)28:1<53::AID-GLIA7>3.0.CO;2-V"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3528"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15292"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06061.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02563-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22047"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh065"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411618111"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06176blu"},{"key":"e_1_3_3_30_2","unstructured":"American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association Washington DC) 4th Ed."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305814110"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.10.013"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-06983.2000"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1510456112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1510456112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:15:19Z","timestamp":1649808919000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1510456112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,8]]},"references-count":34,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2015,9,22]]}},"alternative-id":["10.1073\/pnas.1510456112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1510456112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,8]]},"assertion":[{"value":"2015-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}