{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:19:08Z","timestamp":1790230748117,"version":"4.1.0"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"39","license":[{"start":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T00:00:00Z","timestamp":1440979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["306105"],"award-info":[{"award-number":["306105"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Conventional mosquito-control methods are becoming less effective in controlling mosquito-borne diseases because of widespread resistance against safe and recommended public health insecticides. Therefore innovative and effective alternatives are urgently needed. We present a novel method for exposing mosquitoes to insecticides that uses electrostatic forces to bind insecticide particles. Results show that this method increases exposure of mosquitoes to such an extent that even those that have developed high levels of resistance can be killed effectively. The ability to boost the efficacy of WHO-recommended insecticides provides a significant benefit to the field of vector-borne disease control and will further the development of novel resistance-breaking control tools.<\/jats:p>","DOI":"10.1073\/pnas.1510801112","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T22:19:53Z","timestamp":1441059593000},"page":"12081-12086","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes"],"prefix":"10.1073","volume":"112","author":[{"given":"Rob","family":"Andriessen","sequence":"first","affiliation":[{"name":"In2Care BV, Wageningen 6709 PG, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Snetselaar","sequence":"additional","affiliation":[{"name":"In2Care BV, Wageningen 6709 PG, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco A.","family":"Suer","sequence":"additional","affiliation":[{"name":"In2Care BV, Wageningen 6709 PG, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Osinga","sequence":"additional","affiliation":[{"name":"In2Care BV, Wageningen 6709 PG, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Deschietere","sequence":"additional","affiliation":[{"name":"CTF2000, Zele 9240, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa N.","family":"Lyimo","sequence":"additional","affiliation":[{"name":"Environmental Health and Ecological Sciences Thematic Group, Ifakara Health Institute, Ifakara, Tanzania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladslaus L.","family":"Mnyone","sequence":"additional","affiliation":[{"name":"Environmental Health and Ecological Sciences Thematic Group, Ifakara Health Institute, Ifakara, Tanzania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil D.","family":"Brooke","sequence":"additional","affiliation":[{"name":"Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa;"},{"name":"Vector Control Reference Laboratory, Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham, Johannesburg 2131, South Africa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Ranson","sequence":"additional","affiliation":[{"name":"Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart G. J.","family":"Knols","sequence":"additional","affiliation":[{"name":"In2Care BV, Wageningen 6709 PG, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Farenhorst","sequence":"additional","affiliation":[{"name":"In2Care BV, Wageningen 6709 PG, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,8,31]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2008.07.004"},{"key":"e_1_3_3_3_2","unstructured":"; WHO World Malaria Report 2014 (World Health Organization Geneva) Available at www.who.int\/malaria\/publications\/world_malaria_report_2014\/en\/. Accessed June 3 2015. (2014)."},{"key":"e_1_3_3_4_2","unstructured":"; WHO Global Plan for Insecticide Resistance Management in Malaria Vectors (World Health Organization Geneva) Available at www.who.int\/malaria\/publications\/atoz\/gpirm\/en\/. Accessed June 3 2015. (2012)."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2010.140619"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.08.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0431"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0404.980410"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.67.617"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1406"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.45.1.371"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672397003029"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013300108134"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007485314000091"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-113"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.05.003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1079\/BER2003261"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087710"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075134"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055781"},{"key":"e_1_3_3_21_2","first-page":"387","article-title":"Evaluation of compounds for insecticidal activity on adult mosquitos. 5. Toxicity to adult mosquitos and residual properties of some pyrethroids","volume":"42","author":"Hadaway AB","year":"1970","unstructured":"AB Hadaway, F Barlow, JE Grose, CR Turner, LS Flower, Evaluation of compounds for insecticidal activity on adult mosquitos. 5. Toxicity to adult mosquitos and residual properties of some pyrethroids. Bull World Health Organ 42, 387\u2013398 (1970).","journal-title":"Bull World Health Organ"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-333"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2005.01501.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1748"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1603\/EC10063"},{"key":"e_1_3_3_26_2","unstructured":"; WHO Guidelines for Monitoring the Durability of Long-Lasting Insecticidal Mosquito Nets Under Operational Conditions (World Health Organization Geneva) Available at www.who.int\/malaria\/publications\/atoz\/9789241501705\/en\/. Accessed June 3 2015. (2011)."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.10.008"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2003.00460.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-113"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1079\/BER2001108"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2915.2000.00234.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1179\/000349802125002581"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01336.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2007.03.003"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-3-22"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-200"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012081"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908530106"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70045-8"},{"key":"e_1_3_3_40_2","unstructured":"; WHO Guidelines for Testing Mosquito Alduticides for Indoor Residual Spraying and Treatment of Mosquito Nets (World Health Organization Geneva) Available at https:\/\/extranet.who.int\/iris\/restricted\/handle\/10665\/69296. Accessed June 3 2015. (2006)."},{"key":"e_1_3_3_41_2","unstructured":"; WHO Report of the Twelfth WHOPES Working Group Meeting (World Health Organization Geneva) Available at www.who.int\/whopes\/recommendations\/wgm\/en\/. Accessed June 3 2015. (2009)."},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-499"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1510801112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1510801112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:57:31Z","timestamp":1649807851000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1510801112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,31]]},"references-count":42,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2015,9,29]]}},"alternative-id":["10.1073\/pnas.1510801112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1510801112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,31]]},"assertion":[{"value":"2015-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}