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This motif shares similarity with certain bacterial virulence factors that stimulate actin polymerization in infected human cells, suggesting that similar activation mechanisms have evolved in humans and bacterial pathogens.<\/jats:p>","DOI":"10.1073\/pnas.1510876112","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T23:14:28Z","timestamp":1447110868000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Allosteric N-WASP activation by an inter-SH3 domain linker in Nck"],"prefix":"10.1073","volume":"112","author":[{"given":"Julia","family":"Okrut","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158;"},{"name":"The Howard Hughes Medical Institute Summer Institute, Marine Biological Laboratory, Woods Hole, MA 02543;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J. 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