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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Limiting access of intracellular iron to intracellular microbes is a critical arm of the nutritional immune response. Little is known about the mechanisms used by intravacuolar pathogens to overcome this attempted starvation. We show here that\n                    <jats:italic>Legionella pneumophila<\/jats:italic>\n                    employs its major virulence-associated secretion system to deliver a unique transmembrane protein into host cells during infection. Utilizing microscopic, biochemical, and transcriptional analysis of intracellular bacteria, we demonstrate that the MavN protein integrates into the host-derived vacuolar membrane and facilitates transport of essential iron into the lumen of the vacuole to promote bacterial growth. These findings shed light on what is likely to be a myriad of strategies used by bacteria to overcome potent host nutrient restrictions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1511389112","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T22:19:24Z","timestamp":1441145964000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["MavN is a\n                    <i>Legionella pneumophila<\/i>\n                    vacuole-associated protein required for efficient iron acquisition during intracellular growth"],"prefix":"10.1073","volume":"112","author":[{"given":"Dervla T.","family":"Isaac","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Biology, Tufts University School of Medicine, Boston, MA 02111;"},{"name":"Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA 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