{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:09:01Z","timestamp":1793945341135,"version":"4.8.0"},"reference-count":62,"publisher":"National Academy of Sciences","issue":"20","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26221305"],"award-info":[{"award-number":["26221305"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["25860352"],"award-info":[{"award-number":["25860352"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["15K08521"],"award-info":[{"award-number":["15K08521"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,5,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    A substantial proportion of people have intractable chronic allergic diseases for which no curative treatment exists. A clear understanding of how these allergic diseases develop and persist is lacking. Here, unique ectopic lymphoid-like structures called inducible bronchus-associated lymphoid tissue were found to be formed during chronic airway inflammation, and were critical in persistent inflammation. In addition, we identified a Thy1\n                    <jats:sup>+<\/jats:sup>\n                    IL-7\n                    <jats:sup>+<\/jats:sup>\n                    IL-33\n                    <jats:sup>+<\/jats:sup>\n                    subset of lymphatic endothelial cells (LECs) that support the maintenance of memory-type pathogenic T helper 2 (Tpath2) cells. A similar population of IL-7\n                    <jats:sup>+<\/jats:sup>\n                    IL-33\n                    <jats:sup>+<\/jats:sup>\n                    LECs was found in nasal polyps of patients with eosinophilic chronic rhinosinusitis. Thus, we revealed that Thy1\n                    <jats:sup>+<\/jats:sup>\n                    IL-7\u2013producing LECs control chronic allergic airway inflammation by supporting memory-type Tpath2 cells in human and mouse systems.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1512600113","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T22:23:30Z","timestamp":1462227810000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":123,"title":["Thy1\n                    <sup>+<\/sup>\n                    IL-7\n                    <sup>+<\/sup>\n                    lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation"],"prefix":"10.1073","volume":"113","author":[{"given":"Kenta","family":"Shinoda","sequence":"first","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, 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