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One singularity of this region is its quasi-palindromic structure conserved in the\n                    <jats:italic>3\u2032RR<\/jats:italic>\n                    of other species. By comparing previous mouse knockout (KO) models (\n                    <jats:italic>3\u2032RR-<\/jats:italic>\n                    and\n                    <jats:italic>hs3b-4<\/jats:italic>\n                    KO) to a novel mutant devoid of the quasi-palindrome (\n                    <jats:italic>3\u2032PAL<\/jats:italic>\n                    KO), we highlighted common features and differences that specify two distinct regulatory entities: (\n                    <jats:italic>i<\/jats:italic>\n                    ) the distal module (\n                    <jats:italic>hs4<\/jats:italic>\n                    ) is sufficient for normal IgH expression up to the na\u00efve B cell stage; (\n                    <jats:italic>ii<\/jats:italic>\n                    ) during B-cell activation, the proximal module (quasi-palindrome) is important for both class switch recombination and somatic hypermutation; and (\n                    <jats:italic>iii<\/jats:italic>\n                    ) in plasma cells, the quasi-palindrome is required for robust transcription of the IgH locus.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1514090113","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T23:45:31Z","timestamp":1454370331000},"page":"1618-1623","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Sequential activation and distinct functions for distal and proximal modules within the IgH 3\u2032 regulatory region"],"prefix":"10.1073","volume":"113","author":[{"given":"Armand","family":"Garot","sequence":"first","affiliation":[{"name":"Contr\u00f4le de la R\u00e9ponse Immune B et des Lymphoprolif\u00e9rations, UMR 7276, Centre National de la Recherche Scientifique, Universit\u00e9 de Limoges, 87025 Limoges, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Marquet","sequence":"additional","affiliation":[{"name":"Contr\u00f4le de la R\u00e9ponse Immune B et des Lymphoprolif\u00e9rations, UMR 7276, Centre National de la Recherche Scientifique, Universit\u00e9 de Limoges, 87025 Limoges, France;"},{"name":"Service de N\u00e9phrologie, Centre Hospitalier Universitaire Dupuytren, F-87042 Limoges, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Saintamand","sequence":"additional","affiliation":[{"name":"Contr\u00f4le de la R\u00e9ponse Immune B et des Lymphoprolif\u00e9rations, UMR 7276, Centre National de la Recherche Scientifique, Universit\u00e9 de Limoges, 87025 Limoges, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Bender","sequence":"additional","affiliation":[{"name":"Contr\u00f4le de la R\u00e9ponse Immune B et des Lymphoprolif\u00e9rations, UMR 7276, Centre National de la Recherche Scientifique, Universit\u00e9 de Limoges, 87025 Limoges, France;"},{"name":"Centre de R\u00e9f\u00e9rence des Amyloses, Centre 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