{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:17:29Z","timestamp":1790000249626,"version":"4.0.1"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"37","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The role of the microRNA (miR) 15\/16 family in oncogenesis and tumor progression has been intensively studied. The miR-15a\/16-1 cluster is extensively described in B-cell chronic lymphocytic leukemia, characterized by the deletion of the 13q14 locus. The role of the miR-15b\/16-2 cluster on chromosome 3q25 is still far from being elucidated. Because miR-15a is highly similar to miR-15b and miR-16-1 is identical to miR-16-2, we generated miR-15b\/16-2 knockout mice to better understand the cluster\u2019s role in vivo. These knockout mice developed B-cell lymphomas by age 15\u201318 mo, modulating the\n                    <jats:italic>CCND2<\/jats:italic>\n                    (Cyclin D2),\n                    <jats:italic>CCND1<\/jats:italic>\n                    (Cyclin D1), and\n                    <jats:italic>IGF1R<\/jats:italic>\n                    (insulin-like growth factor 1 receptor) genes involved in proliferation and antiapoptotic pathways in mouse B cells. Our results suggest a tumor suppressor role for the miR-15b\/16-2 cluster in animal models of B-cell lymphomas.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1514954112","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T22:19:53Z","timestamp":1441059593000},"page":"11636-11641","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["miR-15b\/16-2 deletion promotes B-cell malignancies"],"prefix":"10.1073","volume":"112","author":[{"given":"Francesca","family":"Lovat","sequence":"first","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Padua 35121, Italy;"},{"name":"Applied Research on Cancer Network (ARC-NET) Research Centre, University of Verona, Verona 37126, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Rizzotto","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Cascione","sequence":"additional","affiliation":[{"name":"Lymphoma and Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland;"},{"name":"Oncology Institute of Southern Switzerland, Bellinzona 6500, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pizzi","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Padua 35121, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Vicentini","sequence":"additional","affiliation":[{"name":"Applied Research on Cancer Network (ARC-NET) Research Centre, University of Verona, Verona 37126, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Balatti","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Costinean","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Croce","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,8,31]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050995"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506654102"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.69"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242606799"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800121105"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.11.019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.255"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210186"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2663"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","unstructured":"I Satzger MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. 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