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In the present study, the combination of the JAK inhibitor ruxolitinib and the Bcl-2\/Bcl-xL inhibitor navitoclax provided additive\/synergistic antitumor efficacy in IL-2\u2013dependent ATL cell lines and in a mouse model of human ATL as well as with ex vivo peripheral blood mononuclear cells (PBMCs) from ATL patients compared with either drug alone, supporting a therapeutic trial of this combination in patients with ATL.<\/jats:p>","DOI":"10.1073\/pnas.1516208112","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T23:41:16Z","timestamp":1442965276000},"page":"12480-12485","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["Selective targeting of JAK\/STAT signaling is potentiated by Bcl-xL blockade in IL-2\u2013dependent adult T-cell leukemia"],"prefix":"10.1073","volume":"112","author":[{"given":"Meili","family":"Zhang","sequence":"first","affiliation":[{"name":"Lymphoid Malignancies 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