{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:06:53Z","timestamp":1791284813094,"version":"4.1.0"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,10,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Cerebral malaria (CM) is a deadly complication of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    infection in African children despite effective antimalarial treatment. Once signs of neurologic disease have commenced, there is no adjunctive treatment for CM, and overall mortality remains high. Thus, a treatment that arrests disease and promotes healing in the late stages is urgently needed. Here we report, in an animal model of CM, that the glutamine analog 6-diazo-5-oxo-L-norleucine (DON) is an effective therapy even when treatment is initiated after infected animals show neurological signs of disease. Within hours of DON treatment blood\u2013brain barrier integrity was restored, and brain swelling was reduced. These results suggest DON as a strong candidate for an effective adjunctive therapy for CM in African children.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1516544112","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T22:58:48Z","timestamp":1444085928000},"page":"13075-13080","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["Targeting glutamine metabolism rescues mice from late-stage cerebral malaria"],"prefix":"10.1073","volume":"112","author":[{"given":"Emile B.","family":"Gordon","sequence":"first","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey T.","family":"Hart","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan M.","family":"Tran","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Waisberg","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55454;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Pena","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takele","family":"Yazew","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Feng","family":"Qi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Fang","family":"Lee","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;"},{"name":"Chang-Gung Transplantation Institute, Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Taoyuan 333, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Lo","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, 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