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U.S.A."],"published-print":{"date-parts":[[2016,4,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The large-conductance, voltage-gated, calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    )-activated potassium channel (BK\n                    <jats:sub>Ca<\/jats:sub>\n                    ) plays an important role in regulating the membrane potential of uterine muscle cells. We demonstrate that BK\n                    <jats:sub>Ca<\/jats:sub>\n                    interacts with the immunomodulator \u03b1-2-macroglobulin (\u03b1\n                    <jats:sub>2<\/jats:sub>\n                    M) and its receptor low-density lipoprotein receptor-related protein 1 in human uterine muscle cells isolated from pregnant women. Furthermore, we report that activated \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    M regulates BK\n                    <jats:sub>Ca<\/jats:sub>\n                    activity and that activated \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    M and BK\n                    <jats:sub>Ca<\/jats:sub>\n                    together control Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations in the cells, a process dependent on store-operated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    entry. This study reveals a previously unidentified modulator of the BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channel and may imply a link between inflammatory processes and excitation changes in the uterine muscle during pregnancy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1516863113","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T23:51:28Z","timestamp":1459813888000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["BK\n                    <sub>Ca<\/sub>\n                    channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells"],"prefix":"10.1073","volume":"113","author":[{"given":"Monali","family":"Wakle-Prabagaran","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n A.","family":"Lorca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Stamnes","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinwendu","family":"Amazu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordy J.","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-5547","authenticated-orcid":false,"given":"Celeste M.","family":"Karch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof L.","family":"Hyrc","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"England","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242;"},{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199811000-00001"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(03)00089-3"},{"key":"e_1_3_3_3_2","first-page":"3","volume-title":"Uterine Contractility. 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