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Surprisingly, a protective\n                    <jats:italic>CD33<\/jats:italic>\n                    allele is derived and unique to humans, despite weak direct selection on older individuals. We identified several genes with derived alleles that protect against neurodegenerative disease and cerebrovascular insufficiency in old age. Selection by inclusive fitness may be strong enough to favor alleles that protect against cognitive decline in postreproductive humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1517951112","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T23:15:18Z","timestamp":1448925318000},"page":"74-79","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":65,"title":["Human-specific derived alleles of\n                    <i>CD33<\/i>\n                    and other genes protect against postreproductive cognitive decline"],"prefix":"10.1073","volume":"113","author":[{"given":"Flavio","family":"Schwarz","sequence":"first","affiliation":[{"name":"Center for Academic Research and Training in Anthropogeny, University of California, San Diego, La Jolla, CA 92093;"},{"name":"Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093;"},{"name":"Department of 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