{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:23:51Z","timestamp":1793381031550,"version":"4.5.0"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,4,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Lysergic acid diethylamide (LSD), the prototypical \u201cpsychedelic,\u201d may be unique among psychoactive substances. In the decades that followed its discovery, the magnitude of its effect on science, the arts, and society was unprecedented. LSD produces profound, sometimes life-changing experiences in microgram doses, making it a particularly powerful scientific tool. Here we sought to examine its effects on brain activity, using cutting-edge and complementary neuroimaging techniques in the first modern neuroimaging study of LSD. Results revealed marked changes in brain blood flow, electrical activity, and network communication patterns that correlated strongly with the drug\u2019s hallucinatory and other consciousness-altering properties. These results have implications for the neurobiology of consciousness and for potential applications of LSD in psychological research.<\/jats:p>","DOI":"10.1073\/pnas.1518377113","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:43:10Z","timestamp":1460421790000},"page":"4853-4858","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":786,"title":["Neural correlates of the LSD experience revealed by multimodal neuroimaging"],"prefix":"10.1073","volume":"113","author":[{"given":"Robin L.","family":"Carhart-Harris","sequence":"first","affiliation":[{"name":"Centre for Neuropsychopharmacology, Department of Medicine, Imperial College London, W12 0NN, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Muthukumaraswamy","sequence":"additional","affiliation":[{"name":"Department of Psychology, Cardiff University Brain Research Imaging Centre, CF10 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