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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,1,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Transmissible cancers are somatic cell lineages that are spread between individuals via the transfer of living cancer cells. Only three transmissible cancers have been reported in nature, suggesting that such diseases emerge rarely. One of the known transmissible cancers affects Tasmanian devils, and is threatening this species with extinction. Here we report the discovery of a second transmissible cancer in Tasmanian devils. This cancer causes facial tumors that are grossly indistinguishable from those caused by the first-described transmissible cancer in this species; however, tumors derived from this second clone are genetically distinct. These findings indicate that Tasmanian devils have spawned at least two different transmissible cancers, and suggest that transmissible cancers may arise more frequently in nature than previously considered.<\/jats:p>","DOI":"10.1073\/pnas.1519691113","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T22:34:01Z","timestamp":1451342041000},"page":"374-379","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":238,"title":["A second transmissible cancer in Tasmanian devils"],"prefix":"10.1073","volume":"113","author":[{"given":"Ruth J.","family":"Pye","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Save the Tasmanian Devil Program, Tasmanian Department of Primary Industries, Parks, Water and the Environment, Hobart, TAS 7000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Tovar","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M. 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Bruce","family":"Lyons","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P.","family":"Murchison","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Woods","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2015.02.042","article-title":"Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams","volume":"161","author":"Metzger MJ","year":"2015","unstructured":"MJ Metzger, C Reinisch, J Sherry, SP Goff, Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams. 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Science 331, 303 (2011).","journal-title":"Science"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"8536","DOI":"10.1158\/0008-5472.CAN-09-2159","article-title":"Cell fusion as a hidden force in tumor progression","volume":"69","author":"Lu X","year":"2009","unstructured":"X Lu, Y Kang, Cell fusion as a hidden force in tumor progression. Cancer Res 69, 8536\u20138539 (2009).","journal-title":"Cancer Res"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-4939-2703-6_2","article-title":"Fusion in cancer: An explanatory model for aneuploidy, metastasis formation, and drug resistance","volume":"1313","author":"Mohr M","year":"2015","unstructured":"M Mohr, KS Zaenker, T Dittmar, Fusion in cancer: An explanatory model for aneuploidy, metastasis formation, and drug resistance. 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