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We demonstrate here that a genetic modification in the mouse that increases the expression of an endogenous antiinflammatory protein, tristetraprolin (TTP), results in protection against mouse models for several human inflammatory diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis, presumably by decreasing the production of proinflammatory cytokines. Our results suggest that increasing TTP expression may be an effective therapeutic strategy in the treatment of certain inflammatory diseases.<\/jats:p>","DOI":"10.1073\/pnas.1519906113","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T23:45:31Z","timestamp":1454370331000},"page":"1865-1870","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":87,"title":["Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies"],"prefix":"10.1073","volume":"113","author":[{"given":"Sonika","family":"Patial","sequence":"first","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Alan D.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, Greenville, NC 27858;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wi S.","family":"Lai","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Stumpo","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgette D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Integrated Laboratory Systems, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon P.","family":"Flake","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Mannie","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, Greenville, NC 27858;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry J.","family":"Blackshear","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709;"},{"name":"Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300945"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2013.02.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80411-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5379.1001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2389"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.6.4311"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00945-06"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)46259-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402059200"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400900200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103700"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120707"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.393"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1385"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343801"},{"key":"e_1_3_3_16_2","first-page":"15.1.1","article-title":"Experimental autoimmune encephalomyelitis in the mouse","volume":"78","author":"Miller SD","year":"2007","unstructured":"SD Miller, WJ Karpus, Experimental autoimmune encephalomyelitis in the mouse. 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