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In conjunction with our biochemical findings, we synthesize a model of how XPC performs both its evolutionarily conserved DNA repair function and its evolutionarily nonconserved transcription function.<\/jats:p>","DOI":"10.1073\/pnas.1520104112","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T22:03:41Z","timestamp":1447711421000},"page":"14817-14822","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Architecture of the human XPC DNA repair and stem cell coactivator complex"],"prefix":"10.1073","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-2372","authenticated-orcid":false,"given":"Elisa T.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Li Ka Shing Center for Biomedical and Health Sciences, CIRM Center of Excellence, University of California Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"He","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Grob","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yick W.","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Nogales","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Tjian","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;"},{"name":"Li Ka Shing Center for Biomedical and Health Sciences, CIRM Center of Excellence, University of California Berkeley, CA 94720;"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrg2781","article-title":"Inducible gene expression: Diverse regulatory mechanisms","volume":"11","author":"Weake VM","year":"2010","unstructured":"VM Weake, JL Workman, Inducible gene expression: Diverse regulatory mechanisms. 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